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Optimization of Radiochemical Reactions using Droplet Arrays
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JoVE Journal Chimica
Optimization of Radiochemical Reactions using Droplet Arrays

Optimization of Radiochemical Reactions using Droplet Arrays

DOI:
10.3791/62056-v

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10:54 min

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February 12, 2021

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, , ,
1Physics and Biology in Medicine Interdepartmental Graduate Program,University of California Los Angeles (UCLA), 2Crump Institute of Molecular Imaging,UCLA, 3Department of Molecular & Medical Pharmacology,David Geffen School of Medicine, 4Department of Bioengineering,UCLA

Capitoli

  • 00:05Introduction
  • 01:00Planning and Optimizing the Study
  • 01:37Preparation of Reagents and Materials for Optimizing the Radiosynthesis of [18F]Fallypride
  • 03:11Parallel Synthesis of [18F]Fallypride with Different Precursor Concentrations
  • 06:02Synthesis Analysis to Determine Reaction Performance and Optimal Conditions
  • 08:55Results: Influence of Precursor Concentration on the Microdroplet Synthesis of [18F]Fallypride
  • 10:08Conclusion

Summary

Traduzione automatica

Traduzione automatica

This method describes the use of a novel high-throughput methodology, based on droplet chemical reactions, for the rapid and economical optimization of radiopharmaceuticals using nanomole amounts of reagents.

Tags

Radiochemical ReactionsDroplet ArraysAutomated Radio SynthesizersFDGPrecursor ConcentrationFallyprideMicrodroplet ChipsPhotolithographyThexyl AlcoholAcetonitrileSerial DilutionsCrude Reaction ProductCollection SolutionFluoride Stock Solution

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