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Injicerbare supramolelekylære polymer-nanopartikelhydrogeler til anvendelse til levering af celler og lægemidler
JoVE Journal
Bioingegneria
This content is Free Access.
JoVE Journal Bioingegneria
Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
DOI:

09:39 min

February 07, 2021

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Capitoli

  • 00:04Introduction
  • 00:49Nanoparticle (NP) Synthesis
  • 02:10Hydrogel Formulation and Rheological Property Measurement
  • 03:27In Vitro Drug Release Characterization
  • 04:35Thermal Stability of Gel-Encapsulated Insulin Characterization
  • 05:19Cell Viability Assessment
  • 06:08Cell Settling Assessment
  • 07:15Results: Representative Polymer Nanoparticle (PNP) Hydrogel Release Kinetics, Cargo Stability, and Cell Viability
  • 09:00Conclusion

Summary

Traduzione automatica

Denne protokol beskriver syntesen og formuleringen af injicerbare, supramolekyliske polymer-nanopartikel (PNP) hydrogel biomaterialer. Anvendelse af disse materialer til levering af lægemidler, biofarmaceutisk stabilisering og celleindkapsling og -levering demonstreres.

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