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A Rat Lung Transplantation Model of Warm Ischemia/Reperfusion Injury
 

A Rat Lung Transplantation Model of Warm Ischemia/Reperfusion Injury: Optimizations to Improve Outcomes

Article DOI: 10.3791/62445-v • 07:37 min • October 28th, 2021
October 28th, 2021 •
1,2, 1,2, 3, 4, 1, 2,4, 1,2
1Department of Surgery Division of Cardiac Surgery, The Ohio State University Wexner Medical Center, 2The Collaboration for Organ Perfusion, Protection, Engineering and Regeneration (COPPER) Laboratory, The Ohio State University College of Medicine, 3William G. Lowrie Department of Chemical and Biomolecular Engineering, College of Engineering, The Ohio State University, 4Comprehensive Transplant Center, The Ohio State University Wexner Medical Center

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Here, we present optimizations to a rat lung transplantation model that serve to improve outcomes. We provide a size guide for cuffs based on body weight, a measurement strategy to ascertain the 4th intercostal space, and methods of wound closure and BAL (bronchoalveolar lavage) fluid and tissue collection.

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Keywords: Rat Lung Transplantation Warm Ischemia/reperfusion Injury Surgical Technique Cuffing Method Angio-catheter Thoracic Incision Endotracheal Intubation Heparin Administration Molecular Mechanisms Therapeutic Interventions
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