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Portal veneinjektion af kolorektal cancer organoider til at studere levermetastasen Stroma
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1Adelaide Medical School,University of Adelaide, 2South Australian Health and Medical Research Institute (SAHMRI), 3Department of Pathology,Nagoya University Graduate School of Medicine, 4Division of Molecular Pathology, Center for Neurological Disease and Cancer,Nagoya University Graduate School of Medicine, 5Department of Gastroenterology, Graduate School of Medicine,The University of Tokyo, 6Translational and Clinical Research Institute,Newcastle University, 7International Center for Cell and Gene Therapy,Fujita Health University
Capitoli
- 00:04Introduction
- 01:18Portal Vein Injection of Colorectal Cancer Organoids
- 05:39Results: Liver Metastases, Tumor Growth Kinetics, Bone Morphogenetic Protein Signaling and Tumor Proliferation Induced by Portal Vein AAV8-Injection
- 07:29Conclusion
Portal veneinjektion af kolorektal cancer (CRC) organoider genererer stroma-rige levermetastaser. Denne musemodel af CRC-levermetastase repræsenterer et nyttigt redskab til at studere tumor-stroma-interaktioner og udvikle nye stroma-rettede terapier såsom adeno-associerede virusmedierede genterapier.
