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A Mice Model of Chlorhexidine Gluconate-Induced Peritoneal Damage
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JoVE Journal Medicina
A Mice Model of Chlorhexidine Gluconate-Induced Peritoneal Damage

A Mice Model of Chlorhexidine Gluconate-Induced Peritoneal Damage

DOI:
10.3791/63903-v

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04:25 min

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April 28, 2022

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, , , , , ,
1School of Medicine, College of Medicine,I-Shou University, 2Division of Nephrology, Department of Internal Medicine,E-DA Hospital, 3Department of Pediatrics,National Cheng Kung University Hospital, 4Institute of Clinical Medicine, College of Medicine,National Cheng Kung University, 5Division of Nephrology, Department of Internal Medicine,E-DA Dachang Hospital

Capitoli

  • 00:05Introduction
  • 01:01Chemical Preparation and Animal Treatment
  • 01:50Peritoneal Function Tests (Modified Peritoneal Equilibration Test)
  • 03:02Results: Analysis of Fibrosis in the Peritoneal Dialysis Mouse Model
  • 03:54Conclusion

Summary

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The present protocol establishes a peritoneal dialysis (PD) mouse model of chlorhexidine gluconate (CG)-induced peritoneal fibrosis. The current model is simple and easy to use compared to other PD animal models.

Tags

Peritoneal DialysisPDMouse ModelChlorhexidine GluconatePeritoneal FibrosisPeritoneal Function TestDialysis SolutionMasson’s Trichrome StainingVisceral PeritoneumParietal Peritoneum

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