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Destabilization of the Medial Meniscus and Cartilage Scratch Murine Model of Accelerated Osteoarthritis
JoVE Journal
Medicina
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JoVE Journal Medicina
Destabilization of the Medial Meniscus and Cartilage Scratch Murine Model of Accelerated Osteoarthritis

Destabilization of the Medial Meniscus and Cartilage Scratch Murine Model of Accelerated Osteoarthritis

DOI:
10.3791/64159-v

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07:06 min

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July 06, 2022

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, , , ,
1Institute of Biomedical and Environmental Health Research,University of the West of Scotland, 2Institute of Infection, Immunity and Inflammation,University of Glasgow

Capitoli

  • 00:05Introduction
  • 01:08Pre-Operative Care
  • 02:21Destabilization of the Medial Meniscus Procedure Followed by Cartilage Scratch
  • 04:16Post-Operative Care and Evaluation of Osteoarthritic Disease
  • 05:29Results: Destabilization of the Medial Meniscus and Cartilage Scratch Model to Study Post-Traumatic Osteoarthritis
  • 06:24Conclusion

Summary

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The present protocol describes the controlled microblade scratches on the surface of the articular cartilage after destabilizing the mouse knee by cutting the medial miniscotibial ligament. This animal model presents an accelerated form of osteoarthritis (OA) suitable for studying osteophyte formation, osteosclerosis, and early-stage pain.

Tags

MeniscusCartilageOsteoarthritisMouse ModelPost-traumaticOsteophyteEndochondral OssificationPainMedial Meniscotibial LigamentSurgeryAnesthesiaAnalgesiaPatellar LigamentJoint Capsule

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