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Assessment of Nerve Injury-Induced Mechanical Hypersensitivity in Rats Using an Orofacial Operant Pain Assay
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Assessment of Nerve Injury-Induced Mechanical Hypersensitivity in Rats Using an Orofacial Operant Pain Assay

Assessment of Nerve Injury-Induced Mechanical Hypersensitivity in Rats Using an Orofacial Operant Pain Assay

DOI:
10.3791/64221-v

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07:39 min

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July 26, 2022

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, , , , , ,
1Department of Oral and Maxillofacial Surgery,University of Florida, Gainesville, 2Department of Orthodontics,University of Florida, Gainesville, 3Stoelting Co. Wood Dale

Capitoli

  • 00:05Introduction
  • 00:52Setting up the Orofacial Pain Assessment Device (Opad)
  • 01:32Setting up a Protocol and Creating an Experiment File
  • 04:01Training and Baseline Testing Sessions
  • 05:06Induction of Orofacial Neuropathic Pain and Evaluation of Mechanical Hypersensitivity
  • 05:54Results: The Assessment of Mechanical Hypersensitivity in a Rat Model
  • 07:13Conclusion

Summary

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This protocol describes the assessment of mechanical hypersensitivity in a rat model of neuropathic orofacial pain using an operant-based orofacial pain assessment device.

Tags

Keywords: Orofacial Pain Assessment DeviceOPADOperant Reward Conflict ParadigmNociceptionLearningMotivationTranslational ValidityReflex-based AssaysInfraorbital NerveCCI SurgeryMechanical HypersensitivityRatPreclinical Pain ResearchAutomatedExperimenter BiasProtocol SetupApparatusEquipment ModesTesting StagesTreatment GroupsAnimal ID

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