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Left Coronary Artery Ligation: A Surgical Murine Model of Myocardial Infarction
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Left Coronary Artery Ligation: A Surgical Murine Model of Myocardial Infarction

Left Coronary Artery Ligation: A Surgical Murine Model of Myocardial Infarction

DOI:
10.3791/64387-v

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05:48 min

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August 09, 2022

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,
1Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, Department of Medicine,University of Pittsburgh, 2Department of Immunology,University of Pittsburgh, 3Department of Bioengineering, Swanson School of Engineering,University of Pittsburgh

Capitoli

  • 00:05Introduction
  • 00:35Preparation and Endotracheal Intubation of the Mice
  • 02:23Permanent Ligation of the Left Coronary Artery
  • 03:51Post-Operative Care
  • 04:22Results: A Reproducible and Clinically Relevant Myocardial Infarction Murine Model to Improve the Left Coronary Artery Ligation
  • 05:19Conclusion

Summary

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Presented here is a surgical procedure for permanent ligation of the left coronary artery in mice. This model can be used to investigate the pathophysiology and associated inflammatory response after myocardial infarction.

Tags

Left Coronary Artery LigationSurgical Murine ModelMyocardial InfarctionMouse ModelMIAnesthesiaBuprenorphineIntubationVentilatorThoracotomyLeft VentricleLeft Coronary Artery

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