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En musemodell for overgangen av Streptococcus pneumoniae fra kolonisator til patogen ved viral co-infeksjon rekapitulerer aldersforverret sykdom
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1Department of Microbiology and Immunology,University at Buffalo School of Medicine, 2Department of Molecular Biology and Microbiology,Tufts University School of Medicine, 3Graduate Program in Immunology,Tufts Graduate School of Biomedical Sciences, 4Department of Translational Medicine,Lund University, 5Stuart B. Levy Center for the Integrated Management of Antimicrobial Resistance,Tufts University
Capitoli
- 00:05Introduction
- 00:55Growing Streptococcus pneumoniae Biofilm
- 04:15Intranasal Inoculation of Mice with Biofilm-Grown S. pneumoniae
- 05:11Viral Infection with Influenza A Virus (IAV)
- 06:01Processing of Infected Tissues for Bacterial Enumeration
- 08:35Processing of the Lung Samples for Flow Cytometry
- 09:07Results: Enhancement of S. pneumoniae Pathogenicity upon Viral Infection and Advanced Age
- 11:43Conclusion
Dette papiret beskriver en ny musemodell for overgangen av pneumokokker fra en asymptomatisk kolonisator til et sykdomsfremkallende patogen under virusinfeksjon. Denne modellen kan lett tilpasses for å studere polymikrobielle og vertspatogene interaksjoner i de forskjellige faser av sykdomsprogresjon og på tvers av ulike verter.
