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Open source realtids lukket kredsløb elektrisk tærskelsporing til translationel smerteforskning
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1Anaesthesia, Pain, and Critical Care Sciences, School of Physiology, Pharmacology, & Neuroscience,University of Bristol, 2Eli Lilly and Company, 3Department of Computer Science,University of Bristol, 4Department of Aerospace Engineering,University of Bristol, 5Research Computing,University of Bristol
Capitoli
- 00:04Introduction
- 01:29Assembly of the Recording and Stimulating Apparatus
- 03:27Software Setup and Identification and Phenotyping of Peripheral Neurons
- 05:43Latency and Electrical Threshold Tracking
- 08:00Results: Electrical Threshold Tracking of Single‐Neuron Action Potentials
- 09:43Conclusion
APTrack er et software-plugin udviklet til Open Ephys-platformen, der muliggør datavisualisering i realtid og lukket elektrisk tærskelsporing af neuronale handlingspotentialer. Vi har med succes brugt dette i mikroneurografi til humane C-fiber nociceptorer og mus C-fiber og Aδ-fiber nociceptorer.
Tags
Open-sourceReal-timeClosed-loopElectrical Threshold TrackingTranslational Pain ResearchNociceptor SensitizationAutomated Electrical Threshold TrackingNociceptor ExcitabilityBiomarkerAP TrackElectrophysiologyOptogeneticsAcquisition BoardIO BoardIntan RHD Recording HeadstagePulse PalConstant Current StimulatorStepper Motor Control BoardCustom Mounting BracketBarrel Adapter
