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Un modelo de ratón de fibrosis hepática crónica para el estudio de la atresia biliar
JoVE Journal
Immunologia e infezioni
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JoVE Journal Immunologia e infezioni
A Mouse Model of Chronic Liver Fibrosis for the Study of Biliary Atresia
DOI:

09:12 min

February 03, 2023

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Capitoli

  • 00:04Introduction
  • 00:50Establishment of the Chronic Fibrotic BA Mouse Model
  • 01:45Intraperitoneal Injection of the Mice
  • 02:36Collection of Sample Tissue
  • 03:13Fluorescein Angiography of the Extrahepatic Bile Duct
  • 03:41H&E Staining
  • 04:43CK19 and F4/80 Immunohistochemical Staining
  • 06:00Sirius Red Staining
  • 06:55Results: Effects of Anti‐Ly6G Antibody Treatment in a Mouse Model of Biliary Atresia (BA) Infected with RRV
  • 08:42Conclusion

Summary

Traduzione automatica

Establecimos un modelo de ratón de fibrosis hepática crónica, que proporciona un modelo animal adecuado para el estudio mecanicista de fibrosis hepática inducida por virus de la atresia biliar (BA) y una plataforma para futuros tratamientos de BA.

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