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通过生物医学报告 阐明 细胞器通路在疾病中的作用的知识图谱方法
JoVE Journal
Biochimica
This content is Free Access.
JoVE Journal Biochimica
A Knowledge Graph Approach to Elucidate the Role of Organellar Pathways in Disease via Biomedical Reports
DOI:

07:35 min

October 13, 2023

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Capitoli

  • 00:04Introduction
  • 01:09Running the Docker Container
  • 01:53Preparing the Diseases and Proteins
  • 03:16Analyzing the Results
  • 04:20Predictive Analysis
  • 05:40Results: Top Protein‐Disease and Pathway‐Disease Associations and Application of Deep Learning for Knowledge Graph Completion
  • 06:40Conclusion

Summary

Traduzione automatica

介绍了一个计算协议,CaseOLAP LIFT和一个用例,用于研究线粒体蛋白及其与心血管疾病的关联,如生物医学报告中所述。该协议可以很容易地适应研究用户选择的细胞成分和疾病。

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