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In Vivo Brain Tumor Modeling via Electroporation-Based Delivery of Plasmid DNA

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Modellering af hjernetumorer in vivo ved hjælp af elektroporationsbaseret levering af plasmid-DNA, der repræsenterer patientmutationssignaturer

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Modeling Brain Tumors In Vivo Using Electroporation-Based Delivery of Plasmid DNA Representing Patient Mutation Signatures

Modellering af hjernetumorer in vivo ved hjælp af elektroporationsbaseret levering af plasmid-DNA, der repræsenterer patientmutationssignaturer

In Vivo Brain Tumor Modeling via Electroporation-Based Delivery of Plasmid DNA

DOI:

10.3791/65286-v

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02:03 min

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June 23, 2023

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Katie B. Grausam*¹, Joshua J. Breunig*^1,2,3,4,5

¹Board of Governor’s Regenerative Medicine Institute,Cedars-Sinai Medical Center, ²Center for Neural Sciences in Medicine,Cedars-Sinai Medical Center, ³Department of Biomedical Sciences,Cedars-Sinai Medical Center, ⁴Samuel Oschin Comprehensive Cancer Institute,Cedars-Sinai Medical Center, ⁵Department of Medicine, David Geffen School of Medicine,University of California, Los Angeles

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Keywords: Glioblastoma Brain Tumor In Vivo Modeling Electroporation Plasmid DNA Patient Mutation Signatures Immunocompetent Mouse Model Tumor Microenvironment Immunotherapy Autochthonous Tumor Growth Preclinical Trials DNA Plasmids Neural Precursor Cells MADR Method Somatic Mutagenesis Driver Mutations

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