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Genome-Scale Screening to Identify and Compare Therapeutic Targets in Tumors

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Finding New Therapeutic Targets for Malignant Peripheral Nerve Sheath Tumor Through Genome-Scale shRNA Screens (Video) | JoVE

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Genetic Profiling and Genome-Scale Dropout Screening to Identify Therapeutic Targets in Mouse Models of Malignant Peripheral Nerve Sheath Tumor

Finding New Therapeutic Targets for Malignant Peripheral Nerve Sheath Tumor Through Genome-Scale shRNA Screens (Video) | JoVE

Genome-Scale Screening to Identify and Compare Therapeutic Targets in Tumors

DOI:

10.3791/65430-v

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01:41 min

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August 25, 2023

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Brittany Turner-Ivey, Jody Fromm Longo, Dorea P. Jenkins, Stephen T. Guest, Steven L. Carroll²

¹Hollings Cancer Center,Medical University of South Carolina, ²Department of Pathology and Laboratory Medicine,Medical University of South Carolina, ³Department of Computational Medicine and Bioinformatics,University of Michigan, Ann Arbor

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Keywords: Genetic Profiling Genome-scale Dropout Screening Malignant Peripheral Nerve Sheath Tumors NF1 Unbiased Screening Single-cell Sequencing Bioinformatics ErbB3 Lysophosphatidic Acid Receptor 3 Schwann Cells Neurofibromatosis Type 1 Targeted Therapies Functional Genomic Screening

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