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In Situ Mouse Liver Perfusion Model to Study Metabolic Responses to Substrates

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使用灌注小鼠肝脏模型量化肝葡萄糖生成、尿素生成和脂肪分解

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Medicina

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JoVE Journal Medicina

Hepatic Glucose Production, Ureagenesis, and Lipolysis Quantified using the Perfused Mouse Liver Model

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使用灌注小鼠肝脏模型量化肝葡萄糖生成、尿素生成和脂肪分解

In Situ Mouse Liver Perfusion Model to Study Metabolic Responses to Substrates

DOI:

10.3791/65596-v

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01:53 min

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October 06, 2023

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Marie Winther-Sørensen^2,3, Ida Marie Kemp³, Hanne Cathrine Bisgaard, Jens Juul Holst⁵, Nicolai J. Wewer Albrechtsen³

¹Department of Biomedical Sciences, Faculty of Health and Medical Sciences,University of Copenhagen, ²NNF Center for Protein Research, Faculty of Health and Medical Sciences,University of Copenhagen, ³Department for Clinical Biochemistry,Copenhagen University Hospital – Bispebjerg and Frederiksberg, ⁴Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences,University of Copenhagen, ⁵NNF Center for Basic Metabolic Research, Faculty of Health and Medical Sciences,University of Copenhagen

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Keywords: Hepatic Glucose Production Ureagenesis Lipolysis Perfused Mouse Liver Model Liver Metabolism Liver Disease Glucagon Signaling Nutrient Metabolism Liver Biology Liver Perfusion

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