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A Necrotizing Enterocolitis Model for Mechanistic Studies and Drug Discovery

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Mikrofluidisk model af nekrotiserende enterocolitis, der inkorporerer humane neonatale intestinale enteroider og et dysbiotisk mikrobiom

JoVE Journal
Medicina

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JoVE Journal Medicina

Microfluidic Model of Necrotizing Enterocolitis Incorporating Human Neonatal Intestinal Enteroids and a Dysbiotic Microbiome

Mikrofluidisk model af nekrotiserende enterocolitis, der inkorporerer humane neonatale intestinale enteroider og et dysbiotisk mikrobiom

A Necrotizing Enterocolitis Model for Mechanistic Studies and Drug Discovery

DOI:

10.3791/65605-v

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00:57 min

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July 28, 2023

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Lauren C. Frazer, Yukihiro Yamaguchi, Corey M. Jania, Wyatt E. Lanik, Qingqing Gong, Dhirendra K. Singh, Stephen Mackay, Natalia S. Akopyants, Misty Good

¹Division of Neonatal-Perinatal Medicine, Department of Pediatrics,University of North Carolina at Chapel Hill, ²University of Nebraska College of Medicine, ³Department of Surgery,Washington University School of Medicine

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Keywords: Microfluidic Model Necrotizing Enterocolitis Human Neonatal Intestinal Enteroids Dysbiotic Microbiome In Vitro Model NEC-on-a-chip Preterm Neonate Intestinal Organoids Endothelial Cells Pathophysiology Drug Discovery Neonatal Intestinal Diseases

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