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A Comprehensive Protocol for Delivering Intrathecal Injections in Neonatal Mice

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Author Spotlight: Intrathecal Injection – An Efficient and Reliable Delivery Method to Test the Efficacy of Gene Editing in Neonatal Mouse Brains

JoVE Journal
Neuroscienze

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JoVE Journal Neuroscienze

Intrathecal Injection of Newborn Mouse for Genome Editing and Drug Delivery

Author Spotlight: Intrathecal Injection – An Efficient and Reliable Delivery Method to Test the Efficacy of Gene Editing in Neonatal Mouse Brains

A Comprehensive Protocol for Delivering Intrathecal Injections in Neonatal Mice

DOI:

10.3791/65761-v

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02:09 min

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March 08, 2024

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Xiaona Lu, Yong-hui Jiang^2,3

¹Department of Genetics,Yale University School of Medicine, ²Department of Neuroscience,Yale University School of Medicine, ³Department of Pediatrics,Yale University School of Medicine

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Keywords: Intrathecal Injection Newborn Mouse Genome Editing Drug Delivery Neurodevelopmental Disorder Gene Editing Central Nervous System Cerebrospinal Fluid Preclinical Studies Neurobehavioral Analysis IPSC ICV Injection Non-viral Non-nanoparticle

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Author Spotlight: Intrathecal Injection – An Efficient and Reliable Delivery Method to Test the Efficacy of Gene Editing in Neonatal Mouse Brains

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