È necessario avere un abbonamento a JoVE per visualizzare questo. Accedi o inizia la tua prova gratuita.
Capitoli
- 00:00Titolo
- 01:02Introduction
- 02:10Making the Glass Capillary
- 02:52Anesthetizing the Mice
- 03:19Preparing the Mouse for CSF Sampling
- 04:42Collecting CSF Using the Cisterna Magna Puncture Technique
- 06:03After CSF Sampling
- 06:51Conclusion
Transgenic (Tg) mouse models of AD provide an excellent opportunity to investigate how and why Aβ or tau levels in CSF change as the disease progresses in human patients. Here, we demonstrate a refined cisterna magna puncture technique for serial CSF sampling from the mouse.
