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一个串行收集脑脊液从池鼠标麦格纳技术
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Biologia
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JoVE Journal Biologia
A Technique for Serial Collection of Cerebrospinal Fluid from the Cisterna Magna in Mouse
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一个串行收集脑脊液从池鼠标麦格纳技术

DOI:
10.3791/960-v

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08:08 min

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November 10, 2008

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,
1Department of Pathology,Columbia University

Capitoli

  • 00:00Titolo
  • 01:02Introduction
  • 02:10Making the Glass Capillary
  • 02:52Anesthetizing the Mice
  • 03:19Preparing the Mouse for CSF Sampling
  • 04:42Collecting CSF Using the Cisterna Magna Puncture Technique
  • 06:03After CSF Sampling
  • 06:51Conclusion

Summary

Traduzione automatica

Traduzione automatica

转基因（TG）AD小鼠模型提供了一个极好的机会，探讨如何以及为什么脑脊液中的Aβ或tau蛋白水平变化的疾病在人类患者进展。在这里，我们展示了一个串行鼠标脑脊液采样精枕大池穿刺技术。

Tags

Cerebrospinal FluidCSFCisterna MagnaMouseAlzheimer’s DiseaseADNeurodegenerative DiseaseAmyloid PeptideTau ProteinBiochemical ChangesTransgenic Mouse ModelsPuncture TechniqueSamplingAβ42Tau LevelsDisease ProgressionELISAMetabolism

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