Alexander S. Mosig Institute of Biochemistry II Jena University Hospital Biography Publications Institution JoVE Articles Alexander S. Mosig has not added a biography. If you are Alexander S. Mosig and would like to personalize this page please email our Author Liaison for assistance. Publications Downregulation of HNF4A Enables Transcriptomic Reprogramming During the Hepatic Acute-phase Response Communications Biology. May, 2024 | Pubmed ID: 38755249 Organ-on-chip Models for Infectious Disease Research Nature Microbiology. Apr, 2024 | Pubmed ID: 38528150 Modeling of Intravenous Caspofungin Administration Using an Intestine-on-chip Reveals Altered Candida Albicans Microcolonies and Pathogenicity Biomaterials. Jun, 2024 | Pubmed ID: 38489910 Quantification of Polystyrene Uptake by Different Cell Lines Using Fluorescence Microscopy and Label-Free Visualization of Intracellular Polystyrene Particles by Raman Microspectroscopic Imaging Cells. Mar, 2024 | Pubmed ID: 38474417 Tailoring the Degradation Time of Polycationic PEG-Based Hydrogels Toward Dynamic Cell Culture Matrices ACS Applied Bio Materials. Apr, 2024 | Pubmed ID: 38470448 An Organ-on-Chip Platform for Simulating Drug Metabolism Along the Gut-Liver Axis Advanced Healthcare Materials. Mar, 2024 | Pubmed ID: 38452399 Self-Degrading Multifunctional PEG-Based Hydrogels-Tailormade Substrates for Cell Culture Macromolecular Bioscience. May, 2024 | Pubmed ID: 38102978 Asymmetric Block Extension of Star-Shaped [PEG-SH] - Toward Poly(dehydroalanine)-Functionalized PEG Hydrogels for Catch and Release of Charged Guest Molecules Macromolecular Bioscience. Feb, 2024 | Pubmed ID: 37572335 Functional Integration of Natural Killer Cells in a Microfluidically Perfused Liver On-a-chip Model BMC Research Notes. Oct, 2023 | Pubmed ID: 37865791 Evaluation of Drug-induced Liver Toxicity of Trovafloxacin and Levofloxacin in a Human Microphysiological Liver Model Scientific Reports. Aug, 2023 | Pubmed ID: 37587168 Short Chain Fatty Acids: Key Regulators of the Local and Systemic Immune Response in Inflammatory Diseases and Infections Open Biology. Mar, 2023 | Pubmed ID: 36977462 Human Macrophage Polarization Determines Bacterial Persistence of Staphylococcus Aureus in a Liver-on-chip-based Infection Model Biomaterials. Aug, 2022 | Pubmed ID: 35728409 The Natural Compound Atraric Acid Suppresses Androgen-regulated Neo-angiogenesis of Castration-resistant Prostate Cancer Through Angiopoietin 2 Oncogene. Jun, 2022 | Pubmed ID: 35513564 Exploration of Long-Chain Vitamin E Metabolites for the Discovery of a Highly Potent, Orally Effective, and Metabolically Stable 5-LOX Inhibitor That Limits Inflammation Journal of Medicinal Chemistry. Aug, 2021 | Pubmed ID: 34279935 Emulating the Gut-liver Axis: Dissecting the Microbiome's Effect on Drug Metabolism Using Multiorgan-on-chip Models Current Opinion in Endocrine and Metabolic Research. Jun, 2021 | Pubmed ID: 34239997 SARS-CoV-2 Causes Severe Epithelial Inflammation and Barrier Dysfunction Journal of Virology. Apr, 2021 | Pubmed ID: 33637603 Transcript Variants Have Distinct Roles in Ovarian Carcinoma and Differently Influence Platinum Sensitivity and Angiogenesis Cancers. Jan, 2021 | Pubmed ID: 33530588 In Vitro Infection Models to Study Fungal-host Interactions FEMS Microbiology Reviews. Sep, 2021 | Pubmed ID: 33524102 A Versatile and Customizable Low-cost 3D-printed Open Standard for Microscopic Imaging Nature Communications. Nov, 2020 | Pubmed ID: 33239615 Rapid Target Binding and Cargo Release of Activatable Liposomes Bearing HER2 and FAP Single-Chain Antibody Fragments Reveal Potentials for Image-Guided Delivery to Tumors Pharmaceutics. Oct, 2020 | Pubmed ID: 33076292 Lung Infection Results in Down-Regulation of Surfactant Protein-A Mainly Caused by Pro-Inflammatory Macrophages Microorganisms. Apr, 2020 | Pubmed ID: 32316261 VEGF Triggers Transient Induction of Autophagy in Endothelial Cells Via AMPKα1 Cells. Mar, 2020 | Pubmed ID: 32168879 Co-infection with Staphylococcus Aureus After Primary Influenza Virus Infection Leads to Damage of the Endothelium in a Human Alveolus-on-a-chip Model Biofabrication. Feb, 2020 | Pubmed ID: 31994489 The Peroxisome Proliferator-Activated Receptor (PPAR)- Antagonist 2-Chloro-5-Nitro-N-Phenylbenzamide (GW9662) Triggers Perilipin 2 Expression Via PPAR and Induces Lipogenesis and Triglyceride Accumulation in Human THP-1 Macrophages Molecular Pharmacology. Mar, 2020 | Pubmed ID: 31871304 Keeping Commensal: How Lactobacilli Antagonize Pathogenicity of in an Gut Model Disease Models & Mechanisms. Sep, 2019 | Pubmed ID: 31413153 A Three-dimensional Immunocompetent Intestine-on-chip Model As in Vitro Platform for Functional and Microbial Interaction Studies Biomaterials. Nov, 2019 | Pubmed ID: 31398556 CAAP48, a New Sepsis Biomarker, Induces Hepatic Dysfunction in an Liver-on-Chip Model Frontiers in Immunology. 2019 | Pubmed ID: 30873161 Microphysiological Systems Meet HiPSC Technology - New Tools for Disease Modeling of Liver Infections in Basic Research and Drug Development Advanced Drug Delivery Reviews. Feb, 2019 | Pubmed ID: 29908880 β-Glucan Differentiates Human Monocytes Into a Specific Subset of Macrophages Frontiers in Immunology. 2018 | Pubmed ID: 30555483 Functional Analyses of RUNX3 and CaMKIINα in Ovarian Cancer Cell Lines Reveal Tumor-Suppressive Functions for CaMKIINα and Dichotomous Roles for RUNX3 Transcript Variants International Journal of Molecular Sciences. Jan, 2018 | Pubmed ID: 29342962 Preservation of Cell Structure, Metabolism, and Biotransformation Activity of Liver-On-Chip Organ Models by Hypothermic Storage Advanced Healthcare Materials. Jan, 2018 | Pubmed ID: 28960916 Novel Approach for the Prediction of Cell Densities and Viability in Standardized Translucent Cell Culture Biochips with Near Infrared Spectroscopy Engineering in Life Sciences. May, 2017 | Pubmed ID: 32624804 Thermo-responsive Cell Culture Carrier: Effects on Macrophage Functionality and Detachment Efficiency Journal of Tissue Engineering. 2017 | Pubmed ID: 28890781 Tribbles 2 Mediates Cisplatin Sensitivity and DNA Damage Response in Epithelial Ovarian Cancer International Journal of Cancer. Oct, 2017 | Pubmed ID: 28670762 Organ-on-chip Models: New Opportunities for Biomedical Research Future Science OA. Jun, 2017 | Pubmed ID: 28670461 Selective Upregulation of TNFα Expression in Classically-activated Human Monocyte-derived Macrophages (M1) Through Pharmacological Interference with V-ATPase Biochemical Pharmacology. 04, 2017 | Pubmed ID: 28189727 High-Saturated-Fat Diet Increases Circulating Angiotensin-Converting Enzyme, Which Is Enhanced by the Rs4343 Polymorphism Defining Persons at Risk of Nutrient-Dependent Increases of Blood Pressure Journal of the American Heart Association. Jan, 2017 | Pubmed ID: 28096099 Crossing the Blood-brain Barrier: Glutathione-conjugated Poly(ethylene Imine) for Gene Delivery Journal of Controlled Release : Official Journal of the Controlled Release Society. Nov, 2016 | Pubmed ID: 27586188 An Integrative Microfluidically Supported in Vitro Model of an Endothelial Barrier Combined with Cortical Spheroids Simulates Effects of Neuroinflammation in Neocortex Development Biomicrofluidics. Jul, 2016 | Pubmed ID: 27478526 Recruitment of CD16(+) Monocytes to Endothelial Cells in Response to LPS-treatment and Concomitant TNF Release is Regulated by CX3CR1 and Interfered by Soluble Fractalkine Cytokine. Jul, 2016 | Pubmed ID: 27031442 Monocyte-induced Recovery of Inflammation-associated Hepatocellular Dysfunction in a Biochip-based Human Liver Model Scientific Reports. Feb, 2016 | Pubmed ID: 26902749 A Human Macrophage-hepatocyte Co-culture Model for Comparative Studies of Infection and Replication of Francisella Tularensis LVS Strain and Subspecies Holarctica and Mediasiatica BMC Microbiology. Jan, 2016 | Pubmed ID: 26739172 A Microfluidically Perfused Three Dimensional Human Liver Model Biomaterials. Dec, 2015 | Pubmed ID: 26322723 Author Spotlight: Developing a Microfluidic Lung-on-Chip Model for In-Depth Study of Human Immune Response and Infection Mechanisms Hristina Koceva1, Mona Amiratashani1, Knut Rennert2, Alexander S. Mosig1,3,4 1Institute of Biochemistry II, Jena University Hospital, 2Dynamic42 GmbH, 3Center for Sepsis Control and Care, Jena University Hospital, 4Jena School of Microbial Communication, Friedrich Schiller University Jena JoVE 66602 면역학 및 감염병학 Author Spotlight: Developing Immunocompetent Organ-on-Chip Models for Infectious Disease Research Adrian Feile*1,2,3, Valentin D. Wegner*1, Martin Raasch4, Alexander S. Mosig1,2,3,5 1Institute of Biochemistry II, Jena University Hospital, 2Cluster of Excellence Balance of the Microverse, Friedrich Schiller University, 3Jena School of Microbial Communication, Friedrich Schiller University, 4Dynamic42 GmbH, 5Jena Center for Sepsis Control and Care, Jena University Hospital JoVE 66603 면역학 및 감염병학
Author Spotlight: Developing a Microfluidic Lung-on-Chip Model for In-Depth Study of Human Immune Response and Infection Mechanisms Hristina Koceva1, Mona Amiratashani1, Knut Rennert2, Alexander S. Mosig1,3,4 1Institute of Biochemistry II, Jena University Hospital, 2Dynamic42 GmbH, 3Center for Sepsis Control and Care, Jena University Hospital, 4Jena School of Microbial Communication, Friedrich Schiller University Jena JoVE 66602 면역학 및 감염병학
Author Spotlight: Developing Immunocompetent Organ-on-Chip Models for Infectious Disease Research Adrian Feile*1,2,3, Valentin D. Wegner*1, Martin Raasch4, Alexander S. Mosig1,2,3,5 1Institute of Biochemistry II, Jena University Hospital, 2Cluster of Excellence Balance of the Microverse, Friedrich Schiller University, 3Jena School of Microbial Communication, Friedrich Schiller University, 4Dynamic42 GmbH, 5Jena Center for Sepsis Control and Care, Jena University Hospital JoVE 66603 면역학 및 감염병학