David L. Wiest

Publications

• E Proteins Control the Development of NKγδT Cells Through Their Invariant T Cell Receptor
  Nature Communications. Jun, 2024  |   Pubmed ID: 38871720
• Disruption of Polyunsaturated Fatty Acid Biosynthesis Drives STING-dependent Acute Myeloid Leukemia Cell Maturation and Death
  The Journal of Biological Chemistry. May, 2024  |   Pubmed ID: 38522521
• Tissue-infiltrating Alloreactive T Cells Require Id3 to Deflect PD-1-mediated Immune Suppression During GVHD
  Blood. Jan, 2024  |   Pubmed ID: 37871574
• Doubling Down to Make Killer T Cells
  Nature Immunology. Sep, 2023  |   Pubmed ID: 37620604
• Transcription Factor EGR2 Controls Homing and Pathogenicity of T17 Cells in the Central Nervous System
  Nature Immunology. Aug, 2023  |   Pubmed ID: 37443284
• Zebrafish: A Tractable Model for Analysis of T Cell Development
  Methods in Molecular Biology (Clifton, N.J.). 2023  |   Pubmed ID: 36374469
• Development of γδ T Cells: Soldiers on the Front Lines of Immune Battles
  Methods in Molecular Biology (Clifton, N.J.). 2023  |   Pubmed ID: 36374451
• Investigation of the Causal Etiology in a Patient with T-B+NK+ Immunodeficiency
  Frontiers in Immunology. 2022  |   Pubmed ID: 35967429
• IL27 Signaling Serves As an Immunologic Checkpoint for Innate Cytotoxic Cells to Promote Hepatocellular Carcinoma
  Cancer Discovery. Aug, 2022  |   Pubmed ID: 35723626
• The ERK2-DBP Domain Opposes Pathogenesis of a Mouse JAK2V617F-driven Myeloproliferative Neoplasm
  Blood. Jul, 2022  |   Pubmed ID: 35436326
• Loss of Ribosomal Protein Paralog Rpl22-like1 Blocks Lymphoid Development Without Affecting Protein Synthesis
  Journal of Immunology (Baltimore, Md. : 1950). Feb, 2022  |   Pubmed ID: 35046107
• A Novel Germline Heterozygous Variant Causing Severe Atopic Disease and Immune Dysregulation
  Frontiers in Immunology. 2021  |   Pubmed ID: 34887873
• Ontogenic Timing, T cell Receptor Signal Strength, and Notch Signaling Direct γδ T cell Functional Differentiation In vivo
  Cell Reports. Jun, 2021  |   Pubmed ID: 34107257
• The E Protein-TCF1 Axis Controls γδ T cell Development and Effector Fate
  Cell Reports. Feb, 2021  |   Pubmed ID: 33535043
• NeuroD1 Dictates Tumor Cell Differentiation in Medulloblastoma
  Cell Reports. Jun, 2020  |   Pubmed ID: 32579914
• Recent Advances in Understanding the Development and Function of γδ T Cells
  F1000Research. 2020  |   Pubmed ID: 32399190
• RPL22L1 Induction in Colorectal Cancer is Associated with Poor Prognosis and 5-FU Resistance
  PloS One. 2019  |   Pubmed ID: 31581233
• Gadd45 Stress Sensors in Suppression of Leukemia
  Oncotarget. Sep, 2018  |   Pubmed ID: 30344933
• Functional Genomic Landscape of Acute Myeloid Leukaemia
  Nature. Oct, 2018  |   Pubmed ID: 30333627
• Id3 Restricts γδ NKT Cell Expansion by Controlling Egr2 and C-Myc Activity
  Journal of Immunology (Baltimore, Md. : 1950). Sep, 2018  |   Pubmed ID: 30012846
• Integration of T-cell Receptor, Notch and Cytokine Signals Programs Mouse γδ T-cell Effector Differentiation
  Immunology and Cell Biology. Oct, 2018  |   Pubmed ID: 29754419
• Reply to Chien: Clarification of the Effect of Ligand on γδ-TCR Repertoire Selection
  Proceedings of the National Academy of Sciences of the United States of America. Apr, 2018  |   Pubmed ID: 29615510
• Role of a Selecting Ligand in Shaping the Murine γδ-TCR Repertoire
  Proceedings of the National Academy of Sciences of the United States of America. Feb, 2018  |   Pubmed ID: 29432160
• HEB is Required for the Specification of Fetal IL-17-producing γδ T Cells
  Nature Communications. Dec, 2017  |   Pubmed ID: 29222418
• Disruption of Thrombocyte and T Lymphocyte Development by a Mutation in
  Journal of Immunology (Baltimore, Md. : 1950). Dec, 2017  |   Pubmed ID: 29127144
• Non-coding Transcription Instructs Chromatin Folding and Compartmentalization to Dictate Enhancer-Promoter Communication and T Cell Fate
  Cell. Sep, 2017  |   Pubmed ID: 28938112
• THEMIS-tery is Solved
  Nature Immunology. Mar, 2017  |   Pubmed ID: 28323266
• The Homeoprotein Dlx5 Drives Murine T-cell Lymphomagenesis by Directly Transactivating Notch and Upregulating Akt Signaling
  Oncotarget. Feb, 2017  |   Pubmed ID: 28122332
• Ribosomal Proteins Rpl22 and Rpl22l1 Control Morphogenesis by Regulating Pre-mRNA Splicing
  Cell Reports. Jan, 2017  |   Pubmed ID: 28076796
• JUN is a Key Transcriptional Regulator of the Unfolded Protein Response in Acute Myeloid Leukemia
  Leukemia. 05, 2017  |   Pubmed ID: 27840425
• Multisystem Anomalies in Severe Combined Immunodeficiency with Mutant BCL11B
  The New England Journal of Medicine. Dec, 2016  |   Pubmed ID: 27959755
• Rpl22 Loss Selectively Impairs αβ T Cell Development by Dysregulating Endoplasmic Reticulum Stress Signaling
  Journal of Immunology (Baltimore, Md. : 1950). Sep, 2016  |   Pubmed ID: 27489283
• Mutations in STN1 Cause Coats Plus Syndrome and Are Associated with Genomic and Telomere Defects
  The Journal of Experimental Medicine. Jul, 2016  |   Pubmed ID: 27432940
• The BRCA1-Δ11q Alternative Splice Isoform Bypasses Germline Mutations and Promotes Therapeutic Resistance to PARP Inhibition and Cisplatin
  Cancer Research. May, 2016  |   Pubmed ID: 27197267
• Ribosomal Protein Rpl22 Controls the Dissemination of T-cell Lymphoma
  Cancer Research. Jun, 2016  |   Pubmed ID: 27197189
• Appl1 and Appl2 Are Expendable for Mouse Development But Are Essential for HGF-Induced Akt Activation and Migration in Mouse Embryonic Fibroblasts
  Journal of Cellular Physiology. May, 2016  |   Pubmed ID: 26445298
• Using the Zebrafish Model to Study T Cell Development
  Methods in Molecular Biology (Clifton, N.J.). 2016  |   Pubmed ID: 26294415
• Development of γδ T Cells, the Special-Force Soldiers of the Immune System
  Methods in Molecular Biology (Clifton, N.J.). 2016  |   Pubmed ID: 26294395
• Regulatory Roles of Rpl22 in Hematopoiesis: An Old Dog with New Tricks
  Critical Reviews in Immunology. 2015  |   Pubmed ID: 26853850
• Mutagenesis Screen Identifies Agtpbp1 and Eps15L1 As Essential for T Lymphocyte Development in Zebrafish
  PloS One. 2015  |   Pubmed ID: 26161877
• Rpl22 Loss Impairs the Development of B Lymphocytes by Activating a P53-Dependent Checkpoint
  Journal of Immunology (Baltimore, Md. : 1950). Jan, 2015  |   Pubmed ID: 25416806
• Noncanonical Mode of ERK Action Controls Alternative αβ and γδ T Cell Lineage Fates
  Immunity. Dec, 2014  |   Pubmed ID: 25526308
• Origins of γδ T Cell Effector Subsets: a Riddle Wrapped in an Enigma
  Journal of Immunology (Baltimore, Md. : 1950). Nov, 2014  |   Pubmed ID: 25326547
• Fli-1 Regulates the DN2 to DN3 Thymocyte Transition and Promotes γδ T-cell Commitment by Enhancing TCR Signal Strength
  European Journal of Immunology. Sep, 2014  |   Pubmed ID: 24935715
• Enforcement of γδ-lineage Commitment by the Pre-T-cell Receptor in Precursors with Weak γδ-TCR Signals
  Proceedings of the National Academy of Sciences of the United States of America. Apr, 2014  |   Pubmed ID: 24706811
• The TCR Ligand-inducible Expression of CD73 Marks γδ Lineage Commitment and a Metastable Intermediate in Effector Specification
  The Journal of Experimental Medicine. Feb, 2014  |   Pubmed ID: 24493796
• The Ribosomal Protein Rpl22 Controls Ribosome Composition by Directly Repressing Expression of Its Own Paralog, Rpl22l1
  PLoS Genetics. 2013  |   Pubmed ID: 23990801
• Control of Hematopoietic Stem Cell Emergence by Antagonistic Functions of Ribosomal Protein Paralogs
  Developmental Cell. Feb, 2013  |   Pubmed ID: 23449473
• A Role for Ly108 in the Induction of Promyelocytic Zinc Finger Transcription Factor in Developing Thymocytes
  Journal of Immunology (Baltimore, Md. : 1950). Mar, 2013  |   Pubmed ID: 23355739
• Development of Promyelocytic Leukemia Zinc Finger-expressing Innate CD4 T Cells Requires Stronger T-cell Receptor Signals Than Conventional CD4 T Cells
  Proceedings of the National Academy of Sciences of the United States of America. Oct, 2012  |   Pubmed ID: 22988097
• Inactivation of Ribosomal Protein L22 Promotes Transformation by Induction of the Stemness Factor, Lin28B
  Blood. Nov, 2012  |   Pubmed ID: 22976955
• CD45-deficient Severe Combined Immunodeficiency Caused by Uniparental Disomy
  Proceedings of the National Academy of Sciences of the United States of America. Jun, 2012  |   Pubmed ID: 22689986
• Tcra Enhancer Activation by Inducible Transcription Factors Downstream of Pre-TCR Signaling
  Journal of Immunology (Baltimore, Md. : 1950). Apr, 2012  |   Pubmed ID: 22357628
• Developmental Arrest of T Cells in Rpl22-deficient Mice is Dependent Upon Multiple P53 Effectors
  Journal of Immunology (Baltimore, Md. : 1950). Jul, 2011  |   Pubmed ID: 21690328
• Cutting Edge: Intrinsic Programming of Thymic γδT Cells for Specific Peripheral Tissue Localization
  Journal of Immunology (Baltimore, Md. : 1950). Dec, 2010  |   Pubmed ID: 21068400
• Appl1 is Dispensable for Akt Signaling in Vivo and Mouse T-cell Development
  Genesis (New York, N.Y. : 2000). Sep, 2010  |   Pubmed ID: 20665729
• Differential Roles of IL-2-inducible T Cell Kinase-mediated TCR Signals in Tissue-specific Localization and Maintenance of Skin Intraepithelial T Cells
  Journal of Immunology (Baltimore, Md. : 1950). Jun, 2010  |   Pubmed ID: 20483745
• Towards a Molecular Understanding of the Differential Signals Regulating Alphabeta/gammadelta T Lineage Choice
  Seminars in Immunology. Aug, 2010  |   Pubmed ID: 20471282
• Marked Induction of the Helix-loop-helix Protein Id3 Promotes the Gammadelta T Cell Fate and Renders Their Functional Maturation Notch Independent
  Immunity. Oct, 2009  |   Pubmed ID: 19833086
• Recurrent Chromosomal Rearrangements Implicate Oncogenes Contributing to T-cell Lymphomagenesis in Lck-MyrAkt2 Transgenic Mice
  Genes, Chromosomes & Cancer. Sep, 2009  |   Pubmed ID: 19530243
• Identification of the Last Cog in a Ligand-independent Signaling Machine?
  Journal of Immunology (Baltimore, Md. : 1950). May, 2009  |   Pubmed ID: 19380757
• Disruption of Supv3L1 Damages the Skin and Causes Sarcopenia, Loss of Fat, and Death
  Mammalian Genome : Official Journal of the International Mammalian Genome Society. Feb, 2009  |   Pubmed ID: 19145458
• Sustained Expression of Pre-TCR Induced Beta-catenin in Post-beta-selection Thymocytes Blocks T Cell Development
  Journal of Immunology (Baltimore, Md. : 1950). Jan, 2009  |   Pubmed ID: 19124718
• Pre-TCR-induced Beta-catenin Facilitates Traversal Through Beta-selection
  Journal of Immunology (Baltimore, Md. : 1950). Jan, 2009  |   Pubmed ID: 19124717
• Egr2 is Required for Bcl-2 Induction During Positive Selection
  Journal of Immunology (Baltimore, Md. : 1950). Dec, 2008  |   Pubmed ID: 19017967
• Early Growth Response Genes Regulate B Cell Development, Proliferation, and Immune Response
  Journal of Immunology (Baltimore, Md. : 1950). Oct, 2008  |   Pubmed ID: 18802061
• A Novel Recurrent Chromosomal Inversion Implicates the Homeobox Gene Dlx5 in T-cell Lymphomas from Lck-Akt2 Transgenic Mice
  Cancer Research. Mar, 2008  |   Pubmed ID: 18316591
• Early Growth Response 1 and NF-ATc1 Act in Concert to Promote Thymocyte Development Beyond the Beta-selection Checkpoint
  Journal of Immunology (Baltimore, Md. : 1950). Oct, 2007  |   Pubmed ID: 17878368
• High-sensitivity Detection and Quantitative Analysis of Native Protein-protein Interactions and Multiprotein Complexes by Flow Cytometry
  Science's STKE : Signal Transduction Knowledge Environment. Jun, 2007  |   Pubmed ID: 17551170
• T-B+NK+ Severe Combined Immunodeficiency Caused by Complete Deficiency of the CD3zeta Subunit of the T-cell Antigen Receptor Complex
  Blood. Apr, 2007  |   Pubmed ID: 17170122
• Recent Insights into the Signals That Control Alphabeta/gammadelta-lineage Fate
  Immunological Reviews. Feb, 2006  |   Pubmed ID: 16448543
• Attenuation of GammadeltaTCR Signaling Efficiently Diverts Thymocytes to the Alphabeta Lineage
  Immunity. May, 2005  |   Pubmed ID: 15894277
• Enforced Expression of Spi-B Reverses T Lineage Commitment and Blocks Beta-selection
  Journal of Immunology (Baltimore, Md. : 1950). May, 2005  |   Pubmed ID: 15879115
• Low Activation Threshold As a Mechanism for Ligand-independent Signaling in Pre-T Cells
  Journal of Immunology (Baltimore, Md. : 1950). Mar, 2003  |   Pubmed ID: 12626535
• Early Growth Response Transcription Factors Are Required for Development of CD4(-)CD8(-) Thymocytes to the CD4(+)CD8(+) Stage
  Journal of Immunology (Baltimore, Md. : 1950). Feb, 2002  |   Pubmed ID: 11823493
• Extracellular Signal-regulated Kinase (ERK) Activation by the Pre-T Cell Receptor in Developing Thymocytes in Vivo
  The Journal of Experimental Medicine. Dec, 1999  |   Pubmed ID: 10587355
• ZAP-70 Protein Promotes Tyrosine Phosphorylation of T Cell Receptor Signaling Motifs (ITAMs) in Immature CD4(+)8(+) Thymocytes with Limiting P56(lck)
  The Journal of Experimental Medicine. Apr, 1999  |   Pubmed ID: 10190908
• Subunit Composition of Pre-T Cell Receptor Complexes Expressed by Primary Thymocytes: CD3 Delta is Physically Associated but Not Functionally Required
  The Journal of Experimental Medicine. Nov, 1997  |   Pubmed ID: 9348303