Rolf Müller Helmholtz Institute for Pharmaceutical Research Saarland, Department of Microbial Natural Products, Helmholtz Centre for Infection Research and Department of Pharmacy Saarland University Biography Publications Institution JoVE Articles Rolf Müller has not added a biography. If you are Rolf Müller and would like to personalize this page please email our Author Liaison for assistance. Publications Drug Administration Routes Impact the Metabolism of a Synthetic Cannabinoid in the Zebrafish Larvae Model Molecules (Basel, Switzerland). Sep, 2020 | Pubmed ID: 33003405 Amidochelocardin Overcomes Resistance Mechanisms Exerted on Tetracyclines and Natural Chelocardin Antibiotics (Basel, Switzerland). Sep, 2020 | Pubmed ID: 32962088 Natural Products Impacting DNA Methyltransferases and Histone Deacetylases Frontiers in Pharmacology. 2020 | Pubmed ID: 32903500 How to Study the Metabolism of New Psychoactive Substances for the Purpose of Toxicological Screenings-A Follow-Up Study Comparing Pooled Human Liver S9, HepaRG Cells, and Zebrafish Larvae Frontiers in Chemistry. 2020 | Pubmed ID: 32766204 Erratum for Wallenstein Et Al., "ClbR Is the Key Transcriptional Activator of Colibactin Gene Expression in Escherichia Coli" MSphere. Jul, 2020 | Pubmed ID: 32727866 ClbR Is the Key Transcriptional Activator of Colibactin Gene Expression in Escherichia Coli MSphere. 07, 2020 | Pubmed ID: 32669458 Biosynthesis of Cittilins, Unusual Ribosomally Synthesized and Post-translationally Modified Peptides from ACS Chemical Biology. 08, 2020 | Pubmed ID: 32639716 Human Microbial Metabolite Mimicry As a Strategy to Expand the Chemical Space of Potential Drugs Drug Discovery Today. Sep, 2020 | Pubmed ID: 32562605 Dual-Seq Reveals Genome and Transcriptome of Caedibacter Taeniospiralis, Obligate Endosymbiont of Paramecium Scientific Reports. 06, 2020 | Pubmed ID: 32546745 2-Hydroxysorangiadenosine: Structure and Biosynthesis of a Myxobacterial Sesquiterpene-Nucleoside Molecules (Basel, Switzerland). Jun, 2020 | Pubmed ID: 32527018 -Aryl-3-mercaptosuccinimides As Antivirulence Agents Targeting Elastase and Collagenases Journal of Medicinal Chemistry. Aug, 2020 | Pubmed ID: 32470298 Thioholgamide A, a New Anti-Proliferative Anti-Tumor Agent, Modulates Macrophage Polarization and Metabolism Cancers. May, 2020 | Pubmed ID: 32438733 Protein-Templated Hit Identification Through an Ugi Four-Component Reaction Chemistry (Weinheim an Der Bergstrasse, Germany). May, 2020 | Pubmed ID: 32428268 Targeting Cellular Fatty Acid Synthesis Limits T Helper and Innate Lymphoid Cell Function During Intestinal Inflammation and Infection Mucosal Immunology. Apr, 2020 | Pubmed ID: 32355319 Toxicokinetics and Toxicodynamics of the Fentanyl Homologs Cyclopropanoyl-1-benzyl-4´-fluoro-4-anilinopiperidine and Furanoyl-1-benzyl-4-anilinopiperidine Archives of Toxicology. 06, 2020 | Pubmed ID: 32249346 Squalenyl Hydrogen Sulfate Nanoparticles for Simultaneous Delivery of Tobramycin and an Alkylquinolone Quorum Sensing Inhibitor Enable the Eradication of P. aeruginosa Biofilm Infections Angewandte Chemie (International Ed. in English). 06, 2020 | Pubmed ID: 32243047 The ROK Like Protein of Myxococcus Xanthus DK1622 Acts As a Pleiotropic Transcriptional Regulator for Secondary Metabolism Journal of Biotechnology. Mar, 2020 | Pubmed ID: 32057784 The Glucocorticoid-induced Leucine Zipper Mediates Statin-induced Muscle Damage FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Mar, 2020 | Pubmed ID: 32030813 Cystobactamid 507: Concise Synthesis, Mode of Action, and Optimization Toward More Potent Antibiotics Chemistry (Weinheim an Der Bergstrasse, Germany). Jun, 2020 | Pubmed ID: 31984562 Characterization of Bromelain Indicates a Molar Excess of Inhibitor Vs. Enzyme Molecules, a Jacalin-like Lectin and Maillard Reaction Products Journal of Pharmaceutical and Biomedical Analysis. Mar, 2020 | Pubmed ID: 31951942 Myxobacteria-Derived Outer Membrane Vesicles: Potential Applicability Against Intracellular Infections Cells. 01, 2020 | Pubmed ID: 31940898 Structures of Lipoprotein Signal Peptidase II from Staphylococcus Aureus Complexed with Antibiotics Globomycin and Myxovirescin Nature Communications. 01, 2020 | Pubmed ID: 31919415 Semisynthesis and Biological Evaluation of Amidochelocardin Derivatives As Broad-spectrum Antibiotics European Journal of Medicinal Chemistry. Feb, 2020 | Pubmed ID: 31911294 Dual-function Chromogenic Screening-based CRISPR/Cas9 Genome Editing System for Actinomycetes Applied Microbiology and Biotechnology. Jan, 2020 | Pubmed ID: 31788711 PLGA Nanocapsules Improve the Delivery of Clarithromycin to Kill Intracellular Staphylococcus Aureus and Mycobacterium Abscessus Nanomedicine : Nanotechnology, Biology, and Medicine. 02, 2020 | Pubmed ID: 31751769 In Depth Natural Product Discovery - Myxobacterial Strains That Provided Multiple Secondary Metabolites Biotechnology Advances. Mar - Apr, 2020 | Pubmed ID: 31707075 The Cytotoxic Natural Product Vioprolide A Targets Nucleolar Protein 14, Which Is Essential for Ribosome Biogenesis Angewandte Chemie (International Ed. in English). 01, 2020 | Pubmed ID: 31658409 Chemical Synthesis of Tripeptide Thioesters for the Biotechnological Incorporation into the Myxobacterial Secondary Metabolite Argyrin Via Mutasynthesis Beilstein Journal of Organic Chemistry. 2019 | Pubmed ID: 31839838 Homologous Bd Oxidases Share the Same Architecture but Differ in Mechanism Nature Communications. 11, 2019 | Pubmed ID: 31723136 The MRNA-binding Protein TTP/ZFP36 in Hepatocarcinogenesis and Hepatocellular Carcinoma Cancers. Nov, 2019 | Pubmed ID: 31717307 Production of a Dibrominated Aromatic Secondary Metabolite by a Planctomycete Implies Complex Interaction with a Macroalgal Host ACS Chemical Biology. 12, 2019 | Pubmed ID: 31644258 Differential Regulation of AMP-activated Protein Kinase in Healthy and Cancer Cells Explains Why V-ATPase Inhibition Selectively Kills Cancer Cells The Journal of Biological Chemistry. 11, 2019 | Pubmed ID: 31604821 Polyunsaturated Fatty Acid Production by Yarrowia Lipolytica Employing Designed Myxobacterial PUFA Synthases Nature Communications. 09, 2019 | Pubmed ID: 31492836 Watching DNA Replication Inhibitors in Action: Exploiting Time-Lapse Microfluidic Microscopy As a Tool for Target-Drug Interaction Studies in Antimicrobial Agents and Chemotherapy. 10, 2019 | Pubmed ID: 31383667 Connecting Lysosomes and Mitochondria - a Novel Role for Lipid Metabolism in Cancer Cell Death Cell Communication and Signaling : CCS. 07, 2019 | Pubmed ID: 31358011 Production Optimization and Biosynthesis Revision of Corallopyronin A, a Potent Anti-filarial Antibiotic Metabolic Engineering. 09, 2019 | Pubmed ID: 31340171 Chivosazole A Modulates Protein-Protein Interactions of Actin Journal of Natural Products. 07, 2019 | Pubmed ID: 31260301 ACC1 (Acetyl Coenzyme A Carboxylase 1) Is a Potential Immune Modulatory Target of Cerebral Ischemic Stroke Stroke. 07, 2019 | Pubmed ID: 31177975 Integrating Culture-based Antibiotic Resistance Profiles with Whole-genome Sequencing Data for 11,087 Clinical Isolates Genomics, Proteomics & Bioinformatics. 04, 2019 | Pubmed ID: 31100356 A High-affinity Fluorescence Probe for Copper(II) Ions and Its Application in Fluorescence Lifetime Correlation Spectroscopy Analytical and Bioanalytical Chemistry. Jun, 2019 | Pubmed ID: 31025181 Synthesis of New Cyclomarin Derivatives and Their Biological Evaluation Towards Mycobacterium Tuberculosis and Plasmodium Falciparum Chemistry (Weinheim an Der Bergstrasse, Germany). Jul, 2019 | Pubmed ID: 31012978 Targeting Actin Inhibits Repair of Doxorubicin-induced DNA Damage: a Novel Therapeutic Approach for Combination Therapy Cell Death & Disease. 04, 2019 | Pubmed ID: 30944311 A Highly Polymorphic Receptor Governs Many Distinct Self-Recognition Types Within the Order MBio. 02, 2019 | Pubmed ID: 30755513 Engineering Atypical Tetracycline Formation in Amycolatopsis Sulphurea for the Production of Modified Chelocardin Antibiotics ACS Chemical Biology. 03, 2019 | Pubmed ID: 30747520 Dedication: Heinz Floss and Christopher Walsh-pioneers in Natural Product Chemical Biology Journal of Industrial Microbiology & Biotechnology. Mar, 2019 | Pubmed ID: 30729342 Introduction to the Special Issue: "Natural Product Discovery and Development in the Genomic Era: 2019" Journal of Industrial Microbiology & Biotechnology. Mar, 2019 | Pubmed ID: 30729341 Tools for Studying the Metabolism of New Psychoactive Substances for Toxicological Screening Purposes - A Comparative Study Using Pooled Human Liver S9, HepaRG Cells, and Zebrafish Larvae Toxicology Letters. May, 2019 | Pubmed ID: 30682400 Aurantimycin Resistance Genes Contribute to Survival of Listeria Monocytogenes During Life in the Environment Molecular Microbiology. 04, 2019 | Pubmed ID: 30648305 Armeniaspirol Antibiotic Biosynthesis: Chlorination and Oxidative Dechlorination Steps Affording Spiro[4.4]non-8-ene Chembiochem : a European Journal of Chemical Biology. 03, 2019 | Pubmed ID: 30556942 Novel Methoxymethacrylate Natural Products Uncovered by Statistics-Based Mining of the Myxococcus Fulvus Secondary Metabolome ACS Chemical Biology. 01, 2019 | Pubmed ID: 30543288 Class I Methyltransferase VioH Catalyzes Unusual S-Adenosyl-l-methionine Cyclization Leading to 4-Methylazetidinecarboxylic Acid Formation During Vioprolide Biosynthesis ACS Chemical Biology. 01, 2019 | Pubmed ID: 30540188 Corrigendum to Biocompatible Bacteria-derived Vesicles Show Inherent Antimicrobial Activity [Journal of Controlled Release, Volume 290, Page 46-55 (2018), Page 46-55] Journal of Controlled Release : Official Journal of the Controlled Release Society. Jan, 2019 | Pubmed ID: 30529880 Genome Mining Reveals Uncommon Alkylpyrones As Type III PKS Products from Myxobacteria Journal of Industrial Microbiology & Biotechnology. Mar, 2019 | Pubmed ID: 30506464 Expressing Cytotoxic Compounds in Escherichia Coli Nissle 1917 for Tumor-targeting Therapy Research in Microbiology. Mar, 2019 | Pubmed ID: 30447257 -Acylated Amino Acid Methyl Esters from Marine Group Bacteria Beilstein Journal of Organic Chemistry. 2018 | Pubmed ID: 30591820 Aspherical and Spherical InvA497-Functionalized Nanocarriers for Intracellular Delivery of Anti-Infective Agents Pharmaceutical Research. Dec, 2018 | Pubmed ID: 30519925 BAX/BAK-Induced Apoptosis Results in Caspase-8-Dependent IL-1β Maturation in Macrophages Cell Reports. 11, 2018 | Pubmed ID: 30485805 Adaptation of a Bacterial Multidrug Resistance System Revealed by the Structure and Function of AlbA Journal of the American Chemical Society. 12, 2018 | Pubmed ID: 30422653 Synthetic Biology Approaches and Combinatorial Biosynthesis Towards Heterologous Lipopeptide Production Chemical Science. Oct, 2018 | Pubmed ID: 30319751 Biocompatible Bacteria-derived Vesicles Show Inherent Antimicrobial Activity Journal of Controlled Release : Official Journal of the Controlled Release Society. 11, 2018 | Pubmed ID: 30292423 Characterization of an Unusual Glycerate Esterification Process in Vioprolide Biosynthesis ACS Chemical Biology. 11, 2018 | Pubmed ID: 30286293 A Polyphasic Approach Leads to Seven New Species of the Cellulose-decomposing Genus Sorangium, Sorangium Ambruticinum Sp. Nov., Sorangium Arenae Sp. Nov., Sorangium Bulgaricum Sp. Nov., Sorangium Dawidii Sp. Nov., Sorangium Kenyense Sp. Nov., Sorangium Orientale Sp. Nov. and Sorangium Reichenbachii Sp. Nov International Journal of Systematic and Evolutionary Microbiology. Nov, 2018 | Pubmed ID: 30234476 The Vacuolar-type ATPase Inhibitor Archazolid Increases Tumor Cell Adhesion to Endothelial Cells by Accumulating Extracellular Collagen PloS One. 2018 | Pubmed ID: 30204757 The Translational Machinery of Human CD4 T Cells Is Poised for Activation and Controls the Switch from Quiescence to Metabolic Remodeling Cell Metabolism. 12, 2018 | Pubmed ID: 30197303 Metabolic and Biosynthetic Diversity in Marine Myxobacteria Marine Drugs. Sep, 2018 | Pubmed ID: 30189599 Activation of the NLRP3 Inflammasome by Hyaboron, a New Asymmetric Boron-Containing Macrodiolide from the Myxobacterium Hyalangium Minutum ACS Chemical Biology. 10, 2018 | Pubmed ID: 30183250 Future Directions of Marine Myxobacterial Natural Product Discovery Inferred from Metagenomics Marine Drugs. Aug, 2018 | Pubmed ID: 30158489 Simulacricoccus Ruber Gen. Nov., Sp. Nov., a Microaerotolerant, Non-fruiting, Myxospore-forming Soil Myxobacterium and Emended Description of the Family Myxococcaceae International Journal of Systematic and Evolutionary Microbiology. Oct, 2018 | Pubmed ID: 30113300 Iterative Methylations Resulting in the Biosynthesis of the T-Butyl Group Catalyzed by a B-Dependent Radical SAM Enzyme in Cystobactamid Biosynthesis Methods in Enzymology. 2018 | Pubmed ID: 30097093 Structure, Total Synthesis, and Biosynthesis of Chloromyxamides: Myxobacterial Tetrapeptides Featuring an Uncommon 6-Chloromethyl-5-methoxypipecolic Acid Building Block Angewandte Chemie (International Ed. in English). 10, 2018 | Pubmed ID: 30088846 Self-resistance Guided Genome Mining Uncovers New Topoisomerase Inhibitors from Myxobacteria Chemical Science. Jun, 2018 | Pubmed ID: 29910943 A Fluorescence Anisotropy Assay to Discover and Characterize Ligands Targeting the Maytansine site of Tubulin Nature Communications. 05, 2018 | Pubmed ID: 29844393 Concepts and Methods to Access Novel Antibiotics from Actinomycetes Antibiotics (Basel, Switzerland). May, 2018 | Pubmed ID: 29789481 The Alkylquinolone Repertoire of Pseudomonas Aeruginosa is Linked to Structural Flexibility of the FabH-like 2-Heptyl-3-hydroxy-4(1H)-quinolone (PQS) Biosynthesis Enzyme PqsBC Chembiochem : a European Journal of Chemical Biology. Jul, 2018 | Pubmed ID: 29722462 Biosynthesis and Heterologous Production of Vioprolides: Rational Biosynthetic Engineering and Unprecedented 4-Methylazetidinecarboxylic Acid Formation Angewandte Chemie (International Ed. in English). 07, 2018 | Pubmed ID: 29694699 Octapeptins: Lipopeptide Antibiotics Against Multidrug-Resistant Superbugs Cell Chemical Biology. 04, 2018 | Pubmed ID: 29677485 Two Types of Threonine-Tagged Lipopeptides Synergize in Host Colonization by Pathogenic Burkholderia Species ACS Chemical Biology. 05, 2018 | Pubmed ID: 29669203 Discovery of Recombinases Enables Genome Mining of Cryptic Biosynthetic Gene Clusters in Burkholderiales Species Proceedings of the National Academy of Sciences of the United States of America. 05, 2018 | Pubmed ID: 29666226 Genome-wide Mutant Profiling Predicts the Mechanism of a Lipid II Binding Antibiotic Nature Chemical Biology. Apr, 2018 | Pubmed ID: 29662210 Improved Riboflavin Production with Ashbya Gossypii from Vegetable Oil Based on C Metabolic Network Analysis with Combined Labeling Analysis by GC/MS, LC/MS, 1D, and 2D NMR Metabolic Engineering. 05, 2018 | Pubmed ID: 29654833 Correlating Chemical Diversity with Taxonomic Distance for Discovery of Natural Products in Myxobacteria Nature Communications. 02, 2018 | Pubmed ID: 29476047 Nannocystis Konarekensis Sp. Nov., a Novel Myxobacterium from an Iranian Desert International Journal of Systematic and Evolutionary Microbiology. Mar, 2018 | Pubmed ID: 29458458 Production of Extracellular Heterologous Proteins in Streptomyces Rimosus, Producer of the Antibiotic Oxytetracycline Applied Microbiology and Biotechnology. Mar, 2018 | Pubmed ID: 29417200 Biosynthesis of the Klebsiella Oxytoca Pathogenicity Factor Tilivalline: Heterologous Expression, in Vitro Biosynthesis, and Inhibitor Development ACS Chemical Biology. 03, 2018 | Pubmed ID: 29389112 Draft Genome Sequence and Annotation of the Obligate Bacterial Endosymbiont , Causative Agent of the Killer Phenotype in Genome Announcements. Jan, 2018 | Pubmed ID: 29348333 ExoCET: Exonuclease in Vitro Assembly Combined with RecET Recombination for Highly Efficient Direct DNA Cloning from Complex Genomes Nucleic Acids Research. 03, 2018 | Pubmed ID: 29272442 A "Motif-Oriented" Total Synthesis of Nannocystin Ax. Preparation and Biological Assessment of Analogues The Journal of Organic Chemistry. 07, 2018 | Pubmed ID: 29265814 Oxygenated N-Acyl Alanine Methyl Esters (NAMEs) from the Marine Bacterium Roseovarius Tolerans EL-164 Journal of Natural Products. 01, 2018 | Pubmed ID: 29261310 ExoCET: Exonuclease in Vitro Assembly Combined with RecET Recombination for Highly Efficient Direct DNA Cloning from Complex Genomes Nucleic Acids Research. 03, 2018 | Pubmed ID: 29240926 Crocadepsins-Depsipeptides from the Myxobacterium Chondromyces Crocatus Found by a Genome Mining Approach ACS Chemical Biology. 01, 2018 | Pubmed ID: 29220569 Acetyl-CoA Carboxylase 1 Regulates Endothelial Cell Migration by Shifting the Phospholipid Composition Journal of Lipid Research. 02, 2018 | Pubmed ID: 29208696 Homospermidine Lipids: A Compound Class Specifically Formed During Fruiting Body Formation of Myxococcus Xanthus DK1622 ACS Chemical Biology. 01, 2018 | Pubmed ID: 29185703 Targeting De Novo Lipogenesis As a Novel Approach in Anti-cancer Therapy British Journal of Cancer. 01, 2018 | Pubmed ID: 29112683 Biosynthesis of Methyl-proline Containing Griselimycins, Natural Products with Anti-tuberculosis Activity Chemical Science. Nov, 2017 | Pubmed ID: 29163906 The Natural Product Carolacton Inhibits Folate-dependent C1 Metabolism by Targeting FolD/MTHFD Nature Communications. 11, 2017 | Pubmed ID: 29142318 Heterologous Production of Myxobacterial α-pyrone Antibiotics in Myxococcus Xanthus Metabolic Engineering. 11, 2017 | Pubmed ID: 29030273 The Biofilm Inhibitor Carolacton Enters Gram-Negative Cells: Studies Using a TolC-Deficient Strain of MSphere. Sep-Oct, 2017 | Pubmed ID: 28959742 Synthetic Biology Approaches to Establish a Heterologous Production System for Coronatines Metabolic Engineering. 11, 2017 | Pubmed ID: 28951265 Biosynthesis and Total Synthesis of Pyrronazol B: a Secondary Metabolite from Nannocystis Pusilla Chemistry (Weinheim an Der Bergstrasse, Germany). Nov, 2017 | Pubmed ID: 28944573 Linoleic and Palmitoleic Acid Block Streptokinase-mediated Plasminogen Activation and Reduce Severity of Invasive Group A Streptococcal Infection Scientific Reports. 09, 2017 | Pubmed ID: 28924140 CYP17A1-independent Production of the Neurosteroid-derived 5α-pregnan-3β,6α-diol-20-one in Androgen-responsive Prostate Cancer Cell Lines Under Serum Starvation and Inhibition by Abiraterone The Journal of Steroid Biochemistry and Molecular Biology. 11, 2017 | Pubmed ID: 28890368 Total Biosynthesis of the Pyrrolo[4,2]benzodiazepine Scaffold Tomaymycin on an In Vitro Reconstituted NRPS System Cell Chemical Biology. Oct, 2017 | Pubmed ID: 28890318 Optimization of the Biotechnological Production of a Novel Class of Anti-MRSA Antibiotics from Chitinophaga Sancti Microbial Cell Factories. Aug, 2017 | Pubmed ID: 28818083 Total Synthesis of Crocagin A Angewandte Chemie (International Ed. in English). 10, 2017 | Pubmed ID: 28812331 Inhibition of the V-ATPase by Archazolid A: A New Strategy to Inhibit EMT Molecular Cancer Therapeutics. 11, 2017 | Pubmed ID: 28775146 Total Syntheses of Cystobactamids and Structural Confirmation of Cystobactamid 919-2 Angewandte Chemie (International Ed. in English). 10, 2017 | Pubmed ID: 28731542 Pyxipyrrolones: Structure Elucidation and Biosynthesis of Cytotoxic Myxobacterial Metabolites Angewandte Chemie (International Ed. in English). 08, 2017 | Pubmed ID: 28590072 Structure and Biosynthesis of Crocagins: Polycyclic Posttranslationally Modified Ribosomal Peptides from Chondromyces Crocatus Angewandte Chemie (International Ed. in English). 06, 2017 | Pubmed ID: 28544148 AibA/AibB Induces an Intramolecular Decarboxylation in Isovalerate Biosynthesis by Myxococcus Xanthus Angewandte Chemie (International Ed. in English). 08, 2017 | Pubmed ID: 28508504 Heterologous Production and Yield Improvement of Epothilones in Burkholderiales Strain DSM 7029 ACS Chemical Biology. 07, 2017 | Pubmed ID: 28467833 Novel and Revisited Approaches in Antituberculosis Drug Discovery Current Opinion in Biotechnology. 12, 2017 | Pubmed ID: 28427007 Long-Chain Alkyl Cyanides: Unprecedented Volatile Compounds Released by Pseudomonas and Micromonospora Bacteria Angewandte Chemie (International Ed. in English). 04, 2017 | Pubmed ID: 28276609 Selective Upregulation of TNFα Expression in Classically-activated Human Monocyte-derived Macrophages (M1) Through Pharmacological Interference with V-ATPase Biochemical Pharmacology. 04, 2017 | Pubmed ID: 28189727 Vitiosangium Cumulatum Gen. Nov., Sp. Nov. and Vitiosangium Subalbum Sp. Nov., Soil Myxobacteria, and Emended Descriptions of the Genera Archangium and Angiococcus, and of the Family Cystobacteraceae International Journal of Systematic and Evolutionary Microbiology. May, 2017 | Pubmed ID: 28141508 Modulation of Actin Dynamics As Potential Macrophage Subtype-targeting Anti-tumour Strategy Scientific Reports. 01, 2017 | Pubmed ID: 28134280 Solving the Puzzle of One-Carbon Loss in Ripostatin Biosynthesis Angewandte Chemie (International Ed. in English). 02, 2017 | Pubmed ID: 28098952 Disorazoles Block Group A Streptococcal Invasion into Epithelial Cells Via Interference with the Host Factor Ezrin Cell Chemical Biology. Feb, 2017 | Pubmed ID: 28089757 Biosynthesis of Branched Alkoxy Groups: Iterative Methyl Group Alkylation by a Cobalamin-Dependent Radical SAM Enzyme Journal of the American Chemical Society. 02, 2017 | Pubmed ID: 28040895 V-ATPase Inhibition Increases Cancer Cell Stiffness and Blocks Membrane Related Ras Signaling - a New Option for HCC Therapy Oncotarget. Feb, 2017 | Pubmed ID: 28036299 The AibR-isovaleryl Coenzyme A Regulator and Its DNA Binding Site - a Model for the Regulation of Alternative De Novo Isovaleryl Coenzyme A Biosynthesis in Myxococcus Xanthus Nucleic Acids Research. 02, 2017 | Pubmed ID: 27940564 Racemicystis Persica Sp. Nov., a Myxobacterium from Soil International Journal of Systematic and Evolutionary Microbiology. Feb, 2017 | Pubmed ID: 27902273 Heterologous Expression of the Plant Cysteine Protease Bromelain and Its Inhibitor in Pichia Pastoris Biotechnology Progress. 01, 2017 | Pubmed ID: 27860461 Inactivation of SACE_3446, a TetR Family Transcriptional Regulator, Stimulates Erythromycin Production in Synthetic and Systems Biotechnology. Mar, 2016 | Pubmed ID: 29062926 Interrogation of for Efficient Production of Avermectins Synthetic and Systems Biotechnology. Mar, 2016 | Pubmed ID: 29062922 Strategies for the Discovery and Development of New Antibiotics from Natural Products: Three Case Studies Current Topics in Microbiology and Immunology. 2016 | Pubmed ID: 27738913 Structure and Substrate Recognition of the Bottromycin Maturation Enzyme BotP Chembiochem : a European Journal of Chemical Biology. 12, 2016 | Pubmed ID: 27653442 Corrigendum: Transient Hepatic Overexpression of Insulin-Like Growth Factor 2 Induces Free Cholesterol and Lipid Droplet Formation Frontiers in Physiology. 2016 | Pubmed ID: 27489546 Crystal Structure of AibC, a Reductase Involved in Alternative De Novo Isovaleryl Coenzyme A Biosynthesis in Myxococcus Xanthus Acta Crystallographica. Section F, Structural Biology Communications. 08, 2016 | Pubmed ID: 27487931 The Biofilm Inhibitor Carolacton Inhibits Planktonic Growth of Virulent Pneumococci Via a Conserved Target Scientific Reports. 07, 2016 | Pubmed ID: 27404808 Isolation, Structure Elucidation, and (Bio)Synthesis of Haprolid, a Cell-Type-Specific Myxobacterial Cytotoxin Angewandte Chemie (International Ed. in English). 08, 2016 | Pubmed ID: 27404448 Predicting the Presence of Uncommon Elements in Unknown Biomolecules from Isotope Patterns Analytical Chemistry. 08, 2016 | Pubmed ID: 27398867 The Structure of LiuC, a 3-Hydroxy-3-Methylglutaconyl CoA Dehydratase Involved in Isovaleryl-CoA Biosynthesis in Myxococcus Xanthus, Reveals Insights into Specificity and Catalysis Chembiochem : a European Journal of Chemical Biology. 09, 2016 | Pubmed ID: 27271456 RecET Direct Cloning and Redαβ Recombineering of Biosynthetic Gene Clusters, Large Operons or Single Genes for Heterologous Expression Nature Protocols. 07, 2016 | Pubmed ID: 27254463 Discovery of the First Small-molecule CsrA-RNA Interaction Inhibitors Using Biophysical Screening Technologies Future Medicinal Chemistry. 06, 2016 | Pubmed ID: 27253623 Isolation, Structure Elucidation, Biosynthesis, and Synthesis of Antalid, a Secondary Metabolite from Polyangium Species Organic Letters. 06, 2016 | Pubmed ID: 27220069 Transient Hepatic Overexpression of Insulin-Like Growth Factor 2 Induces Free Cholesterol and Lipid Droplet Formation Frontiers in Physiology. 2016 | Pubmed ID: 27199763 Structure-function Analysis for the Hydroxylation of Δ4 C21-steroids by the Myxobacterial CYP260B1 FEBS Letters. 06, 2016 | Pubmed ID: 27177597 Susceptibility of Different Mouse Wild Type Strains to Develop Diet-Induced NAFLD/AFLD-Associated Liver Disease PloS One. 2016 | Pubmed ID: 27167736 MDM2 Antagonist Nutlin-3a Sensitizes Tumors to V-ATPase Inhibition Molecular Oncology. 08, 2016 | Pubmed ID: 27157929 Crystal Structure of the HMG-CoA Synthase MvaS from the Gram-Negative Bacterium Myxococcus Xanthus Chembiochem : a European Journal of Chemical Biology. 07, 2016 | Pubmed ID: 27124816 Room Temperature Electrocompetent Bacterial Cells Improve DNA Transformation and Recombineering Efficiency Scientific Reports. Apr, 2016 | Pubmed ID: 27095488 Racemicystis Crocea Gen. Nov., Sp. Nov., a Soil Myxobacterium in the Family Polyangiaceae International Journal of Systematic and Evolutionary Microbiology. Jun, 2016 | Pubmed ID: 27046779 Overproduction of Magnetosomes by Genomic Amplification of Biosynthesis-Related Gene Clusters in a Magnetotactic Bacterium Applied and Environmental Microbiology. 05, 2016 | Pubmed ID: 26969709 Genetic Engineering and Heterologous Expression of the Disorazol Biosynthetic Gene Cluster Via Red/ET Recombineering Scientific Reports. Feb, 2016 | Pubmed ID: 26875499 Effects of Halide Ions on the Carbamidocyclophane Biosynthesis in Nostoc Sp. CAVN2 Marine Drugs. Jan, 2016 | Pubmed ID: 26805858 Investigations to the Antibacterial Mechanism of Action of Kendomycin PloS One. 2016 | Pubmed ID: 26795276 Genome Analysis of the Fruiting Body-Forming Myxobacterium Chondromyces Crocatus Reveals High Potential for Natural Product Biosynthesis Applied and Environmental Microbiology. Jan, 2016 | Pubmed ID: 26773087 Cylindrofridins A-C, Linear Cylindrocyclophane-Related Alkylresorcinols from the Cyanobacterium Cylindrospermum Stagnale Journal of Natural Products. Jan, 2016 | Pubmed ID: 26684177 The Mechanism of Action of Lysobactin Journal of the American Chemical Society. Jan, 2016 | Pubmed ID: 26683668 Gen. Nov., Sp. Nov. and Sp. Nov., Novel Myxobacteria with Promising Biotechnological Applications International Journal of Systematic and Evolutionary Microbiology. Feb, 2016 | Pubmed ID: 26637815 Metabolic Engineering of Pseudomonas Putida for Production of Docosahexaenoic Acid Based on a Myxobacterial PUFA Synthase Metabolic Engineering. Jan, 2016 | Pubmed ID: 26617065 Mutations Improving Production and Secretion of Extracellular Lipase by Burkholderia Glumae PG1 Applied Microbiology and Biotechnology. Feb, 2016 | Pubmed ID: 26476653 Structural Insights into Anthranilate Priming During Type II Polyketide Biosynthesis ACS Chemical Biology. Jan, 2016 | Pubmed ID: 26473393 Two More Pieces of the Colibactin Genotoxin Puzzle from Show Incorporation of an Unusual 1-aminocyclopropanecarboxylic Acid Moiety Chemical Science. May, 2015 | Pubmed ID: 28706687 Soraphen A: A Probe for Investigating the Role of De Novo Lipogenesis During Viral Infection ACS Infectious Diseases. Mar, 2015 | Pubmed ID: 27622463 Anti-leukemic Effects of the V-ATPase Inhibitor Archazolid A Oncotarget. Dec, 2015 | Pubmed ID: 26496038 Direct Cloning and Heterologous Expression of the Salinomycin Biosynthetic Gene Cluster from Streptomyces Albus DSM41398 in Streptomyces Coelicolor A3(2) Scientific Reports. Oct, 2015 | Pubmed ID: 26459865 Two of a Kind--The Biosynthetic Pathways of Chlorotonil and Anthracimycin ACS Chemical Biology. Nov, 2015 | Pubmed ID: 26348978 Rickenyls A-E, Antioxidative Terphenyls from the Fungus Hypoxylon Rickii (Xylariaceae, Ascomycota) Phytochemistry. Oct, 2015 | Pubmed ID: 26296745 Minimum Information About a Biosynthetic Gene Cluster Nature Chemical Biology. Sep, 2015 | Pubmed ID: 26284661 Cystochromones, Unusual Chromone-Containing Polyketides from the Myxobacterium Cystobacter Sp. MCy9104 Journal of Natural Products. Aug, 2015 | Pubmed ID: 26214047 Macyranones: Structure, Biosynthesis, and Binding Mode of an Unprecedented Epoxyketone That Targets the 20S Proteasome Journal of the American Chemical Society. Jul, 2015 | Pubmed ID: 26050527 Antibiotics. Targeting DnaN for Tuberculosis Therapy Using Novel Griselimycins Science (New York, N.Y.). Jun, 2015 | Pubmed ID: 26045430 Biosynthetic Studies of Telomycin Reveal New Lipopeptides with Enhanced Activity Journal of the American Chemical Society. Jun, 2015 | Pubmed ID: 26043159 AntiSMASH 3.0-a Comprehensive Resource for the Genome Mining of Biosynthetic Gene Clusters Nucleic Acids Research. Jul, 2015 | Pubmed ID: 25948579 Advanced Mutasynthesis Studies on the Natural α-pyrone Antibiotic Myxopyronin from Myxococcus Fulvus Chembiochem : a European Journal of Chemical Biology. Apr, 2015 | Pubmed ID: 25757034 Total Syntheses and Biological Evaluation of Miuraenamides Angewandte Chemie (International Ed. in English). Apr, 2015 | Pubmed ID: 25688545 Rational and Efficient Site-directed Mutagenesis of Adenylation Domain Alters Relative Yields of Luminmide Derivatives in Vivo Biotechnology and Bioengineering. Jul, 2015 | Pubmed ID: 25683597 A New Recombineering System for Photorhabdus and Xenorhabdus Nucleic Acids Research. Mar, 2015 | Pubmed ID: 25539914 Heterologous Expression of an Orphan NRPS Gene Cluster from Paenibacillus Larvae in Escherichia Coli Revealed Production of Sevadicin Journal of Biotechnology. Jan, 2015 | Pubmed ID: 25529345 Anti-MRSA-acting Carbamidocyclophanes H-L from the Vietnamese Cyanobacterium Nostoc Sp. CAVN2 The Journal of Antibiotics. Mar, 2015 | Pubmed ID: 25182484 Aggregicoccus Edonensis Gen. Nov., Sp. Nov., an Unusually Aggregating Myxobacterium Isolated from a Soil Sample International Journal of Systematic and Evolutionary Microbiology. Mar, 2015 | Pubmed ID: 24591423 Elevated Free Cholesterol in a P62 Overexpression Model of Non-alcoholic Steatohepatitis World Journal of Gastroenterology. Dec, 2014 | Pubmed ID: 25548482 De Novo Fatty Acid Synthesis Controls the Fate Between Regulatory T and T Helper 17 Cells Nature Medicine. Nov, 2014 | Pubmed ID: 25282359 Improving Natural Products Identification Through Targeted LC-MS/MS in an Untargeted Secondary Metabolomics Workflow Analytical Chemistry. Nov, 2014 | Pubmed ID: 25280058 In Vitro and in Vivo Characterization of the Actin Polymerizing Compound Chondramide As an Angiogenic Inhibitor Cardiovascular Research. Nov, 2014 | Pubmed ID: 25239826 Heterologous Production of Glidobactins/luminmycins in Escherichia Coli Nissle Containing the Glidobactin Biosynthetic Gene Cluster from Burkholderia DSM7029 Chembiochem : a European Journal of Chemical Biology. Oct, 2014 | Pubmed ID: 25147087 Minicystis Rosea Gen. Nov., Sp. Nov., a Polyunsaturated Fatty Acid-rich and Steroid-producing Soil Myxobacterium International Journal of Systematic and Evolutionary Microbiology. Nov, 2014 | Pubmed ID: 25114157 Antimalarial Activity of the Myxobacterial Macrolide Chlorotonil A Antimicrobial Agents and Chemotherapy. Nov, 2014 | Pubmed ID: 25114138 Targeting V-ATPase in Primary Human Monocytes by Archazolid Potently Represses the Classical Secretion of Cytokines Due to Accumulation at the Endoplasmic Reticulum Biochemical Pharmacology. Oct, 2014 | Pubmed ID: 25107704 A Highly Unusual Polyketide Synthase Directs Dawenol Polyene Biosynthesis in Stigmatella Aurantiaca Journal of Biotechnology. Dec, 2014 | Pubmed ID: 25102237 Hyalachelins A-C, Unusual Siderophores Isolated from the Terrestrial Myxobacterium Hyalangium Minutum Organic Letters. Aug, 2014 | Pubmed ID: 25058569 Interactions of the Natural Product Kendomycin and the 20S Proteasome Journal of Molecular Biology. Sep, 2014 | Pubmed ID: 25038530 Biosynthesis of Crocacin Involves an Unusual Hydrolytic Release Domain Showing Similarity to Condensation Domains Chemistry & Biology. Jul, 2014 | Pubmed ID: 24981773 Secondary Metabolomics: the Impact of Mass Spectrometry-based Approaches on the Discovery and Characterization of Microbial Natural Products Natural Product Reports. Jun, 2014 | Pubmed ID: 24763662 Cystomanamides: Structure and Biosynthetic Pathway of a Family of Glycosylated Lipopeptides from Myxobacteria Organic Letters. May, 2014 | Pubmed ID: 24735013 Biosynthesis of Magnetic Nanostructures in a Foreign Organism by Transfer of Bacterial Magnetosome Gene Clusters Nature Nanotechnology. Mar, 2014 | Pubmed ID: 24561353 V-ATPase Inhibition Regulates Anoikis Resistance and Metastasis of Cancer Cells Molecular Cancer Therapeutics. Apr, 2014 | Pubmed ID: 24482380 Oleamycins A and B: New Antibacterial Cyclic Hexadepsipeptides Isolated from a Terrestrial Streptomyces Sp The Journal of Antibiotics. Apr, 2014 | Pubmed ID: 24448627 Improved Seamless Mutagenesis by Recombineering Using CcdB for Counterselection Nucleic Acids Research. Mar, 2014 | Pubmed ID: 24369425 V-ATPase Inhibition Overcomes Trastuzumab Resistance In breast Cancer Molecular Oncology. Feb, 2014 | Pubmed ID: 24055142 Modular Construction of a Functional Artificial Epothilone Polyketide Pathway ACS Synthetic Biology. Oct, 2014 | Pubmed ID: 23654254 Jahnellamides, α-keto-β-methionine-containing Peptides from the Terrestrial Myxobacterium Jahnella Sp.: Structure and Biosynthesis Organic Letters. Nov, 2013 | Pubmed ID: 24199909 Concerted Action of P450 Plus Helper Protein to Form the Amino-hydroxy-piperidone Moiety of the Potent Protease Inhibitor Crocapeptin Journal of the American Chemical Society. Nov, 2013 | Pubmed ID: 24171398 Microsclerodermins from Terrestrial Myxobacteria: an Intriguing Biosynthesis Likely Connected to a Sponge Symbiont Journal of the American Chemical Society. Nov, 2013 | Pubmed ID: 24124771 Combining in Silico and Biophysical Methods for the Development of Pseudomonas Aeruginosa Quorum Sensing Inhibitors: an Alternative Approach for Structure-based Drug Design Journal of Medicinal Chemistry. Nov, 2013 | Pubmed ID: 24083807 Exploring Chemical Diversity of α-pyrone Antibiotics: Molecular Basis of Myxopyronin Biosynthesis Chembiochem : a European Journal of Chemical Biology. Sep, 2013 | Pubmed ID: 23983106 Discovery and Biological Activity of New Chondramides from Chondromyces Sp Chembiochem : a European Journal of Chemical Biology. Sep, 2013 | Pubmed ID: 23959765 Synthesis and Biological Activities of the Respiratory Chain Inhibitor Aurachin D and New Ring Versus Chain Analogues Beilstein Journal of Organic Chemistry. 2013 | Pubmed ID: 23946854 Oleaceran: a Novel Spiro[isobenzofuran-1,2'-naptho[1,8-bc]furan] Isolated from a Terrestrial Streptomyces Sp Organic Letters. Jul, 2013 | Pubmed ID: 23802119 High-titer Heterologous Production in E. Coli of Lyngbyatoxin, a Protein Kinase C Activator from an Uncultured Marine Cyanobacterium ACS Chemical Biology. Sep, 2013 | Pubmed ID: 23751865 In Vivo Evidence for a Prodrug Activation Mechanism During Colibactin Maturation Chembiochem : a European Journal of Chemical Biology. Jul, 2013 | Pubmed ID: 23744512 Lorneic Acids C and D, New Trialkyl-substituted Aromatic Acids Isolated from a Terrestrial Streptomyces Sp The Journal of Antibiotics. Jun, 2013 | Pubmed ID: 23549352 Enhancer Binding Proteins Act As Hetero-oligomers and Link Secondary Metabolite Production to Myxococcal Development, Motility, and Predation Chemistry & Biology. Nov, 2012 | Pubmed ID: 23177199 Ribosomally Synthesized and Post-translationally Modified Peptide Natural Products: Overview and Recommendations for a Universal Nomenclature Natural Product Reports. Nov, 2012 | Pubmed ID: 23165928 The Interplay of Lung Surfactant Proteins and Lipids Assimilates the Macrophage Clearance of Nanoparticles PloS One. 2012 | Pubmed ID: 22802970 Pretubulysin: from Hypothetical Biosynthetic Intermediate to Potential Lead in Tumor Therapy PloS One. 2012 | Pubmed ID: 22616003 Methods to Optimize Myxobacterial Fermentations Using Off-gas Analysis Microbial Cell Factories. May, 2012 | Pubmed ID: 22571441 Myxobacterium-produced Antibiotic TA (myxovirescin) Inhibits Type II Signal Peptidase Antimicrobial Agents and Chemotherapy. Apr, 2012 | Pubmed ID: 22232277 Molluscicidal Metabolites from an Assemblage of Palmyra Atoll Cyanobacteria Journal of Natural Products. May, 2011 | Pubmed ID: 21473610 Fatty Acid-related Phylogeny of Myxobacteria As an Approach to Discover Polyunsaturated Omega-3/6 Fatty Acids Journal of Bacteriology. Apr, 2011 | Pubmed ID: 21317327 Insights into an Unusual Nonribosomal Peptide Synthetase Biosynthesis: Identification and Characterization of the GE81112 Biosynthetic Gene Cluster The Journal of Biological Chemistry. Oct, 2010 | Pubmed ID: 20710026 Characterization of a Novel Type of Oxidative Decarboxylase Involved in the Biosynthesis of the Styryl Moiety of Chondrochloren from an Acylated Tyrosine The Journal of Biological Chemistry. Apr, 2010 | Pubmed ID: 20080978 Genome Mining in Sorangium Cellulosum So Ce56: Identification and Characterization of the Homologous Electron Transfer Proteins of a Myxobacterial Cytochrome P450 The Journal of Biological Chemistry. Oct, 2009 | Pubmed ID: 19696019 Efficient Transfer of Two Large Secondary Metabolite Pathway Gene Clusters into Heterologous Hosts by Transposition Nucleic Acids Research. Oct, 2008 | Pubmed ID: 18701643 GeneTrail--advanced Gene Set Enrichment Analysis Nucleic Acids Research. Jul, 2007 | Pubmed ID: 17526521 The Unique DKxanthene Secondary Metabolite Family from the Myxobacterium Myxococcus Xanthus is Required for Developmental Sporulation Proceedings of the National Academy of Sciences of the United States of America. Dec, 2006 | Pubmed ID: 17148609 Biosynthetic Pathway of Pseudomonas Aeruginosa 4-hydroxy-2-alkylquinolines Journal of Bacteriology. Jun, 2005 | Pubmed ID: 15901684 Метаболическое профилирование для определения бактерицидных или бактериостатические эффекты новых натуральных продуктов с использованием изотермальной микрокалориметрии Katarina Cirnski*1,2, Janetta Coetzee*1,2, Jennifer Herrmann1,2, Rolf Müller1,2 1Helmholtz Institute for Pharmaceutical Research Saarland, Department of Microbial Natural Products, Helmholtz Centre for Infection Research and Department of Pharmacy, Saarland University, 2Partner Site Hannover-Braunschweig, German Centre for Infection Research (DZIF) JoVE 61703 생체공학
Метаболическое профилирование для определения бактерицидных или бактериостатические эффекты новых натуральных продуктов с использованием изотермальной микрокалориметрии Katarina Cirnski*1,2, Janetta Coetzee*1,2, Jennifer Herrmann1,2, Rolf Müller1,2 1Helmholtz Institute for Pharmaceutical Research Saarland, Department of Microbial Natural Products, Helmholtz Centre for Infection Research and Department of Pharmacy, Saarland University, 2Partner Site Hannover-Braunschweig, German Centre for Infection Research (DZIF) JoVE 61703 생체공학
