Exploring Gut Phage-Bacteria Dynamics in Murine Models Using T4 Phage

January 26, 2024

小鼠肠道中 T4 噬菌体和大肠杆菌相互作用：研究体内宿主-噬菌体动力学的原型模型

Preparation and Purification of T4 Phage Lysates for Oral Administration in Mice

In Vivo Monitoring and Quantification of T4 Phage in Mice Using Fecal Spot Plating Assays

Nicola Pett, Michael Hunter, Natalia A. Carranza García, Jung Hee Seo, Samuel R. Collins, Forest Rohwer, Lisa C. Osborne, Carolina Tropini^3,4

¹Department of Microbiology and Immunology, Life Sciences Institute,University of British Columbia, ²Department of Biology,San Diego State University, ³School of Biomedical Engineering,University of British Columbia, ⁴Humans and the Microbiome Program,Canadian Institute for Advanced Research

Summary

噬菌体（噬菌体）是感染细菌的病毒，是肠道微生物组的一个组成部分。尽管这些共生居民驱动细菌适应性和种群动态，但人们对它们如何影响肠道稳态和疾病知之甚少。该方案研究小鼠模型中分离的T4噬菌体，适应其他噬菌体 – 细菌对。

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