Recording and Analyzing Multimodal Large-Scale Neuronal Ensemble Dynamics on CMOS-Integrated High-Density Microelectrode Array

Brett Addison Emery; Shahrukh Khanzada; Xin Hu; Diana Kl&#252;tsch; Hayder Amin

doi:10.3791/66473

Multimodal Large-Scale Neural Recordings and Analysis on HD-MEA

March 08, 2024

Opptak og analyse av multimodal storskala nevronal ensembledynamikk på CMOS-integrert mikroelektrode med høy tetthet

02:23 min

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Ex-Vivo Brain Slices Preparation from Mouse Brain Tissue for Studying Hippocampal-Cortical and Olfactory Bulb Circuits

01:05 min

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In-Vitro Culture of Human-Induced Pluripotent Stem Cells (iPSC) on High-Density Microelectrode Array (HD-MEA)

01:27 min

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Ex-Vivo Circuit-Wide Recordings from Hippocampal-Cortical and Olfactory Bulb Slices Using High-Density Microelectrode Array (HD-MEA)

01:34 min

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Preparation of Human iPSC Recording Workspace and Network-Wide Recordings on High-Density Microelectrode Array (HD-MEA)

00:54 min

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Analysis of Ex-Vivo Mouse Brain Slices and In-Vitro Human iPSC-Derived Neuronal Networks

02:41 min

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Brett Addison Emery*¹, Shahrukh Khanzada*¹, Xin Hu*¹, Diana Klütsch, Hayder Amin^2,3

¹Group of “Biohybrid Neuroelectronics (BIONICS)”,German Center for Neurodegenerative Diseases (DZNE), ²Faculty of Medicine Carl Gustav Carus,Technical University Dresden, ³Dresden Center for Intelligent Materials (DCIM),Technical University Dresden

Summary

Her bruker vi HD-MEA for å fordype oss i beregningsdynamikken til store nevronale ensembler, spesielt i hippocampus, olfaktoriske pærekretser og menneskelige nevronnettverk. Registrering av spatiotemporal aktivitet, kombinert med beregningsverktøy, gir innsikt i nevronal ensemblekompleksitet. Metoden forbedrer forståelsen av hjernens funksjoner, potensielt identifiserer biomarkører og behandlinger for nevrologiske lidelser.