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Combining the Chandler Loop and RT-FluFF for Ex Vivo Clot Lysis Monitoring

April 19th, 2024
1, 1, 1,2, 1,2
1Department of Emergency Medicine, Indiana University School of Medicine, 2Weldon School of Biomedical Engineering, Purdue University

Summary
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In-vitro thrombolysis assays have often struggled to replicate in-vivo conditions whether in the model thrombus being digested or in the environment in which thrombolysis is occurring. Herein, we explore how coupling the Chandler loop and Real-Time Fluorometric Flowing Fibrinolysis Assay (RT-FluFF) is used for high-fidelity, ex-vivo, clot lysis monitoring.

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