Chongqing Traditional Chinese Medicine Hospital 1 article published in JoVE Medicine Roller Microneedle Combined with Tranexamic Acid Solution in Treating Melasma Wenhao Zheng*1, Sutao Liu*1, Liming Tian2,3, Dan Ke1 1Department of Dermatology, Chongqing Hospital of Traditional Chinese Medicine, 2Department of Dermatology, Hospital of Traditional Chinese and Western Medicine of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, 3Hubei Provincial Key Laboratory of Skin Infection and Immunity, Wuhan No.1 Hospital This article presents a protocol to conduct the treatment of melasma by using roller microneedles in combination with tranexamic acid solution and evaluate the efficacy.