Changchun University of Chinese Medicine 1 article published in JoVE Medicine Establishment of Coloproctitis Cancer Model in Mice and Evaluation of Therapeutic Effect of Chinese Medicine Dongxing Lyu1, Weifang Wang2, Hanying Xu1, Pengfei Li1, Wenyuan Zhang1, Xiangyue Meng1, Shixin Liu3 1College of Traditional Chinese Medicine, Changchun University of Chinese Medicine, 2School of Clinical Medicine, Changchun University of Chinese Medicine, 3Department of Radiotherapy, Jilin Provincial Cancer Hospital This protocol provides a mouse model of ulcerative coloproctitis-associated colorectal cancer induced by azomethane combined with dextran sulfate sodium. The model was used to evaluate the efficacy of traditional Chinese medicine compounds in the prevention and treatment of colorectal cancer.