Jawaharlal Nehru University New Delhi 1 article published in JoVE Biochemistry CD Spectroscopy to Study DNA-Protein Interactions Vijendra Arya1, Anindita Dutta1, Rohini Muthuswami1 1Jawaharlal Nehru University New Delhi The interaction of an ATP-dependent chromatin remodeler with a DNA ligand is described using CD spectroscopy. The induced conformational changes on a gene promoter analyzed by the peaks generated can be used to understand the mechanism of transcriptional regulation.