University Hospital Hamburg View Institution's Website 5 articles published in JoVE Medicine Inducing Myointimal Hyperplasia Versus Atherosclerosis in Mice: An Introduction of Two Valid Models Mandy Stubbendorff*1,2, Xiaoqin Hua*1,2, Tobias Deuse1,2,3, Ziad Ali4,5, Hermann Reichenspurner2,3, Lars Maegdefessel6, Robert C. Robbins7, Sonja Schrepfer1,2,3,4 1Transplant and Stem Cell Immunobiology Lab, Cardiovascular Research Center, University Hospital Hamburg, 2Cardiovascular Research Center (CVRC) and DZHK University Hamburg, 3Department of Cardiovascular Surgery, University Heart Center Hamburg, 4Center for Interventional Vascular Therapy, Division of Cardiology, Columbia University, 5Cardiovascular Research Foundation, New York, 6Karolinska Institute, Stockholm, 7Department of Cardiothoracic Surgery, Stanford University School of Medicine, Falk Cardiovascular Research Center This video shows two models of intimal plaque development in murine arteries and emphasizes the differences in myointimal hyperplasia and atherosclerosis. Bioengineering Bioluminescence Imaging for Assessment of Immune Responses Following Implantation of Engineered Heart Tissue (EHT) Lenard Conradi1,2, Christiane Pahrmann1, Stephanie Schmidt1, Tobias Deuse1,3, Arne Hansen2, Alexandra Eder2, Hermann Reichenspurner1, Robert C. Robbins3, Thomas Eschenhagen2, Sonja Schrepfer1,3 1Transplant and Stem Cell Immunobiology Lab (TSI) and CVRC, University Hospital Hamburg, University Heart Center Hamburg, 2Department of Experimental and Clinical Pharmacology and Toxicology, University Heart Center Hamburg, 3CT Surgery, Stanford University School of Medicine This video demonstrates the use of in vivo bioluminescence imaging to study immune responses after implantation of Engineered Heart Tissue (EHT) in rats. Medicine Orthotopic Aortic Transplantation: A Rat Model to Study the Development of Chronic Vasculopathy Mandy Stubbendorff1, Tobias Deuse1,2, Anna Hammel1, Robert C. Robbins2, Hermann Reichenspurner1, Sonja Schrepfer1,2 1University Heart Center Hamburg, Transplant and Stem Cell Immunobiology Lab (TSI), University Hospital Hamburg, 2Stanford University School of Medicine This video demonstrates the orthotopic aortic transplant model as a simple model to study the development of transplant vasculopathy (TVP) in rats. Biology Heterotopic and Orthotopic Tracheal Transplantation in Mice used as Models to Study the Development of Obliterative Airway Disease Xiaoqin Hua1, Tobias Deuse1,2, Karis R. Tang-Quan1,2,3, Robert C. Robbins3, Hermann Reichenspurner1,2, Sonja Schrepfer1,2,3 1Transplant and Stem Cell Immunobiology Lab (TSI), University Heart Center Hamburg, 2CVRC, University Hospital Hamburg, 3Department of CT Surgery, Stanford University School of Medicine This video shows and compares two experimental models to study the development of obliterative airway disease (OAD) in mice, the heterotopic and orthotopic tracheal transplantation model. Biology LAD-Ligation: A Murine Model of Myocardial Infarction Mandy V.V. Kolk1,2, Danja Meyberg1,2, Tobias Deuse1,2, Karis R. Tang-Quan1,2,3, Robert C. Robbins3, Hermann Reichenspurner1,2, Sonja Schrepfer1,2,3 1Transplant and Stem Cell Immunobiology Lab (TSI), University Heart Center Hamburg, 2CVRC, University Hospital Hamburg, 3Department of CT Surgery, Stanford University School of Medicine This video demonstrates how to use a fast and reliable model to study pathobiological and pathophysiological processes of myocardial ischemia.