Karlsruhe Institute of Technology - Campus Nord 1 article published in JoVE Biology Evaluating Toxicity of Chemicals using a Zebrafish Vibration Startle Response Screening System Gaëlle Hayot1, Daniel Marcato1,2, Christina A. Cramer von Clausbruch1, Giuseppina Pace1, Uwe Strähle1,3, John K. Colbourne4, Christian Pylatiuk5, Ravindra Peravali1, Carsten Weiss1, Stefan Scholz6, Thomas Dickmeis1 1Institute of Biological and Chemical Systems - Biological Information Processing, Karlsruhe Institute of Technology - Campus Nord, 2DITABIS AG - Digital Biomedical Imaging Systems AG, 3Centre for Organismal Studies, Heidelberg University, 4School of Biosciences, University of Birmingham, 5Institute for Automation and Applied Informatics, Karlsruhe Institute of Technology - Campus Nord, 6Department of Bioanalytical Ecotoxicology, Helmholtz-Centre for Environmental Research - UFZ We describe a screening system's workflow and data analysis for evaluating chemical compound toxicity based on the zebrafish embryo vibration startle response. The system records the movements of zebrafish embryos upon exposure to a vibration stimulus and allows for an integrated evaluation of general toxicity/lethality and neuromuscular toxicity.
