Neuro-Bio Ltd 1 article published in JoVE Neuroscience An Alternative Approach to Study Primary Events in Neurodegeneration Using Ex Vivo Rat Brain Slices Emanuele Brai1, Antonella Cogoni1, Susan A. Greenfield1 1Neuro-Bio Ltd, Building F5, Culham Science Centre We present a method which can provide further insights into the early events underlying neurodegeneration and based on the established ex-vivo brain technique, combining the advantages of in vivo and in vitro experiments. Moreover, it represents a unique opportunity for direct comparison of treated and untreated group in the same anatomical plane.