UCSF School of Medicine 1 article published in JoVE Medicine Induction and Phenotyping of Acute Right Heart Failure in a Large Animal Model of Chronic Thromboembolic Pulmonary Hypertension David Boulate1, Myriam Amsallem1,2, Jean-Baptiste Menager1, Simon Dang Van1, Peter Dorfmuller3, Andrew Connolly4, Alban Todesco5, Benoit Decante1, Elie Fadel1, Francois Haddad2, Olaf Mercier1 1Research and Innovation Unit, RHU BioArt Lung 2020, Marie Lannelongue Hospital, 2Phenotypic and Biomarker Core Laboratory, Cardiovascular Institute, Stanford University, 3Department of pathology, Marie Lannelongue Hospital, 4Department of pathology, UCSF School of Medicine, 5Department of thoracic surgery, Hopital Nord, APHM, Aix-Marseille University We present a protocol to induce and phenotype an acute right heart failure in a large animal model with chronic pulmonary hypertension. This model can be used to test therapeutic interventions, to develop right heart metrics or to improve the understanding of acute right heart failure pathophysiology.