Soterix Medical 3 articles published in JoVE Neuroscience Measuring Contralateral Silent Period Induced by Single-Pulse Transcranial Magnetic Stimulation to Investigate M1 Corticospinal Inhibition Ingrid Rebello-Sanchez1, Joao Parente1, Kevin Pacheco-Barrios1,2, Anna Marduy1, Danielle Carolina Pimenta1, Daniel Lima1, Eric Slawka1, Alejandra Cardenas-Rojas1, Gleysson Rodrigues Rosa1, Kamran Nazim3, Abhishek Datta3,4, Felipe Fregni1 1Neuromodulation Center and Center for Clinical Research Learning, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Harvard Medical School, 2Universidad de Investigación para la Generación y Síntesis de Evidencia en Salud, Universidad San Ignacio de Loyola, 3Research and Development, Soterix Medical, 4City College of New York Contralateral silent period (cSP) assessment is a promising biomarker to index cortical excitability and treatment response. We demonstrate a protocol to assess cSP intended for studying M1 corticospinal inhibition of upper and lower limbs. Neuroscience Remotely Supervised Transcranial Direct Current Stimulation: An Update on Safety and Tolerability Michael T. Shaw1, Margaret Kasschau2, Bryan Dobbs1, Natalie Pawlak1, William Pau1, Kathleen Sherman1, Marom Bikson3, Abhishek Datta4, Leigh E. Charvet1 1New York University, Langone Medical Center, 2Stony Brook Medicine, 3City College of New York, 4Soterix Medical This manuscript provides an updated remote supervision protocol that enables participation in transcranial direct current stimulation (tDCS) clinical trials while receiving treatment sessions from home. The protocol has been successfully piloted in both patients with multiple sclerosis and Parkinson's disease. Medicine A Protocol for the Use of Remotely-Supervised Transcranial Direct Current Stimulation (tDCS) in Multiple Sclerosis (MS) Margaret Kasschau1,2, Kathleen Sherman1,2, Lamia Haider2, Ariana Frontario1,2, Michael Shaw1,2, Abhishek Datta3, Marom Bikson4, Leigh Charvet1,2 1Multiple Sclerosis Comprehensive Care Center, Department of Neurology, NYU Langone Medical Center, 2Department of Neurology, Stony Brook Medicine, 3Soterix Medical, Inc, 4Department of Biomedical Engineering, The City College of New York The goal of this pilot study is to describe a protocol for the remotely-supervised delivery of transcranial direct current stimulation (tDCS) so that the procedure maintains standards of in-clinic practice, including safety, reproducibility, and tolerability. The feasibility of this protocol was tested in participants with multiple sclerosis (MS).