National University of Mexico 1 article published in JoVE Neuroscience In Vivo Wireless Optogenetic Control of Skilled Motor Behavior Diana L. Rodriguez-Munoz1, Omar Jaidar2, Marcela Palomero-Rivero1, Mario A. Arias-Garcia3, Gordon W. Arbuthnott4, Violeta G. Lopez-Huerta1 1Institute of Cellular Physiology, National University of Mexico, 2Department of Neurosurgery, Stanford University, 3Facultad de Psicologia, National University of Mexico, 4Brain Mechanisms for Behaviour Unit, Okinawa Institute of Science and Technology Graduate University The present protocol describes how to use wireless optogenetics combined with high-speed videography in a single pellet reach-to-grasp task to characterize the neural circuits involved in the performance of skilled motor behavior in freely moving mice.