Texas Medical Center View Institution's Website 1 article published in JoVE Medicine Preclinical Model of Hind Limb Ischemia in Diabetic Rabbits Andrew D. Sligar1, Gretchen Howe2, Julia Goldman3, Patricia Felli2, Varsha Karanam1, Richard W. Smalling2,4, Aaron B. Baker1,5,6,7 1Department of Biomedical Engineering, University of Texas at Austin, 2Division of Cardiology, University of Texas McGovern Medical School, 3Center for Laboratory Animal Medicine and Care, UT Health Science Center at Houston, 4Memorial Herman Heart and Vascular Center, Texas Medical Center, 5Institute for Cellular and Molecular Biology, University of Texas at Austin, 6The Institute for Computational Engineering and Sciences, University of Texas at Austin, 7Institute for Biomaterials, Drug Delivery and Regenerative Medicine, University of Texas at Austin We describe a surgical procedure used to induce peripheral ischemia in rabbits with hyperlipidemia and diabetes. This surgery acts as a preclinical model for conditions experienced in peripheral artery disease in patients. Angiography is also described as a means to measure the extent of introduced ischemia and recovery of perfusion.