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Chapter 3

Chapter 3

Protein Structure

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Overview Proteins are chains of amino acids that are connected by peptide bonds and folded into a 3-dimensional structure. The side chains of individual …
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Overview Proteins are one of the fundamental building blocks of life that carry out many diverse functions in the cell. Proteins are assembled from amino …
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Overview Proteins are chains of amino acids linked together by peptide bonds. Upon synthesis, a protein folds into a three-dimensional conformation which …
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Protein families are groups of homologous proteins; that is, they have similarities in amino acid sequences and three-dimensional structures. Protein …
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Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally …
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Many proteins can be classified into two distinct subtypes – globular or fibrous. These two types differ in their shapes and solubilities. Globular …
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Intrinsically disordered proteins are a group of proteins that do not fold into specific three-dimensional structures. Their structural flexibility allows …
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Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes …
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Simple proteins and protein complexes contain only amino acids. In contrast, many other proteins, called conjugated proteins, covalently bond with …
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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or …
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Overview Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced …
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Aggregates of the neuronal Tau protein are found inside neurons of Alzheimer’s disease patients. Development of the disease is accompanied by increased, …
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Proteins interact with their ligands to form active and dynamic assemblies which carry out various cellular functions. Elucidating these interactions is …
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Deposition of amyloid beta protein (Aβ) in extra- and intracellular spaces is one of the hallmark pathologies of Alzheimer's disease (AD). …