Chapter 13
Membrane Transport and Active Transporters
![The Significance of Membrane Transport](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/11873.jpg)
The transport of solutes across the cell membrane is essential for metabolic processes, like maintaining cell size and volume, generating the action…
![Membrane Transporters](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/11874.jpg)
Transporters are essential membrane transport proteins with functions related to cell nutrition, homeostasis, communication, etc. Approximately 7% of…
![Primary Active Transport](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/11876.jpg)
In contrast to passive transport, active transport involves a substance being moved through membranes in a direction against its concentration or…
![ATP Driven Pumps I: An Overview](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/11877.jpg)
ATP-driven pumps, also known as transport ATPases, are integral membrane proteins. They have binding sites for ATP located on the membrane's…
![ATP Driven Pumps III: V-type Pumps](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/12218.jpg)
V-type pumps are ATP-driven pumps found in the vacuolar membranes of plants, yeast, endosomal and lysosomal membranes of animal cells, plasma…
![ABC Transporters: Exporter](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/11878.jpg)
ATP-binding cassette or ABC transporter is the largest superfamily of integral membrane proteins. The transporters have transmembrane-binding domains…
![Glucose Transporters](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/12136.jpg)
Glucose transporters facilitate the transport of glucose across the cell membrane. In addition to glucose, some glucose transporters can also aid the…
![Secondary Active Transport](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/11880.jpg)
One example of how cells use the energy contained in electrochemical gradients is demonstrated by glucose transport into cells. The ion vital to this…
![Isolation of F<sub>1</sub>-ATPase from the Parasitic Protist <em>Trypanosoma brucei</em>](https://cloudfront.jove.com/files/thumbs/58334_t.png)
F1-ATPase is a membrane-extrinsic catalytic subcomplex of F-type ATP synthase, an enzyme that uses the proton motive force across biological…
![Chemical Modification of the Tryptophan Residue in a Recombinant Ca<sup>2+</sup>-ATPase N-domain for Studying Tryptophan-ANS FRET](https://cloudfront.jove.com/files/thumbs/62770_t.png)
The sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) is a P-type ATPase that has been crystallized in various conformations. Detailed functional…