All Protocols and Video Articles for scientific research | JoVE

Showing 61 - 72 of 164 videos for "INDEL"

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Journal (Genetics)

Investigation of the Transcriptional Role of a RUNX1 Intronic Silencer by CRISPR/Cas9 Ribonucleoprotein in Acute Myeloid Leukemia Cells

Chi-Keung Cheng, Terry H.Y. Wong, Yuk-Lin Yung, Nelson C.N. Chan, Margaret H.L. Ng²

¹Blood Cancer Cytogenetics and Genomics Laboratory, Department of Anatomical and Cellular Pathology, Prince of Wales Hospital,The Chinese University of Hong Kong, ²State Key Laboratory in Oncology in South China,The Chinese University of Hong Kong

Journal (Bioengineering)

Production of E. coli-expressed Self-Assembling Protein Nanoparticles for Vaccines Requiring Trimeric Epitope Presentation

Christopher P. Karch², Peter Burkhard, Gary R. Matyas, Zoltan Beck²

¹U.S. Military HIV Research Program,Walter Reed Army Institute of Research, ²Henry M. Jackson Foundation for the Advancement of Military Medicine, ³Alpha-O Peptides AG

Journal (Genetics)

Generation of Defined Genomic Modifications Using CRISPR-CAS9 in Human Pluripotent Stem Cells

Fabian L. Cardenas-Diaz*¹, Jean Ann Maguire*¹, Paul Gadue^2,3, Deborah L. French^2,3

¹Center for Cellular and Molecular Therapeutics,The Children's Hospital of Philadelphia, ²Department of Pathology and Laboratory Medicine,The Children's Hospital of Philadelphia, ³Department of Pathology and Laboratory Medicine,University of Pennsylvania

Journal (Immunology and Infection)

Lentiviral CRISPR/Cas9-Mediated Genome Editing for the Study of Hematopoietic Cells in Disease Models

Soichi Sano, Ying Wang, Megan A. Evans, Yoshimitsu Yura, Miho Sano, Hayato Ogawa, Keita Horitani, Heather Doviak, Kenneth Walsh

¹Hematovascular Biology Center, Robert M. Berne Cardiovascular Research Center,University of Virginia School of Medicine

Journal (Genetics)

Transforming, Genome Editing and Phenotyping the Nitrogen-fixing Tropical Cannabaceae Tree Parasponia andersonii

Titis A.K. Wardhani², Yuda Purwana Roswanjaya², Simon Dupin³, Huchen Li⁴, Sidney Linders, Marijke Hartog, Rene Geurts, Arjan van Zeijl

¹Laboratory of Molecular Biology, Department of Plant Sciences,Wageningen University & Research, ²Center of Technology for Agricultural Production,Agency for the Assessment and Application of Technology (BPPT), ³Department of Ecological Science, Faculty of Earth and Life Sciences,Vrije Universiteit Amsterdam, ⁴Beijing Advanced Innovation Center for Tree Breeding by Molecular Design,Beijing University of Agriculture

Journal (Genetics)

Identifying Mutations by High Resolution Melting in a TILLING Population of Rice

Shan Li, Ying-Ping Yu, Song-Mei Liu, Hao-Wei Fu, Jian-Zhong Huang, Qing-Yao Shu, Yuan-Yuan Tan

¹National Key Laboratory of Rice Biology, Zhejiang Provincial Key Laboratory of Crop Genetic Resources, Institute of Crop Science,Zhejiang University, ²Jiaxing Academy of Agricultural Sciences, ³Institute of Nuclear Agricultural Sciences,Zhejiang University, ⁴The New Countryside Development Institute at Zhejiang University

Journal (Genetics)

Characterizing Mutational Load and Clonal Composition of Human Blood

Axel Rosendahl Huber, Freek Manders, Rurika Oka, Ruben van Boxtel

¹Princess Máxima Center for Pediatric Oncology

Journal (Medicine)

Pre-clinical Model of Cardiac Donation after Circulatory Death

Henry Aceros*¹, Leyla Joulali*², Mélanie Borie, Roberto Vanin Pinto Ribeiro, Mitesh Vallabh Badiwala, Shant Der Sarkissian⁴, Nicolas Noiseux⁴

¹Centre de recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), ²Deparment of pharmacology and physiology, Faculty of Medicine,Université de Montréal, ³Division of Cardiovascular Surgery,Toronto General Hospital, University Health Network, ⁴Department of surgery, Faculty of Medicine,Université de Montréal

Journal (Genetics)

Pooled CRISPR-Based Genetic Screens in Mammalian Cells

Katherine Chan*¹, Amy Hin Yan Tong*¹, Kevin R Brown, Patricia Mero, Jason Moffat^2,3

¹Donnelly Centre,University of Toronto, ²Department of Molecular Genetics,University of Toronto, ³Institute for Biomaterials and Biomedical Engineering,University of Toronto

Journal (Genetics)

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

J. Michael Harnish*¹, Samantha L. Deal*², Hsiao-Tuan Chao^3,4,5, Michael F. Wangler^2,4, Shinya Yamamoto^2,4,5

¹Department of Molecular and Human Genetics,Baylor College of Medicine, ²Program in Developmental Biology,Baylor College of Medicine, ³Department of Pediatrics, Section of Neurology and Developmental Neuroscience,Baylor College of Medicine, ⁴Jan and Dan Duncan Neurological Research Institute,Texas Children's Hospital, ⁵Department of Neuroscience,Baylor College of Medicine

Journal (Cancer Research)

Using CRISPR/Cas9 to Knock Out GM-CSF in CAR-T Cells

Rosalie M. Sterner², Michelle J. Cox, Reona Sakemura, Saad S. Kenderian³

¹Mayo Clinic Medical Scientist Training Program,Mayo Clinic College of Medicine and Science, ²Department of Immunology,Mayo Clinic, ³Division of Hematology,Mayo Clinic

Journal (Genetics)

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Julia Wang², Zhandong Liu⁴, Hugo J. Bellen^4,5,6,7, Shinya Yamamoto^4,5,6

¹Program in Developmental Biology,Baylor College of Medicine, ²Medical Scientist Training Program,Baylor College of Medicine, ³Department of Pediatrics,Baylor College of Medicine, ⁴Jan and Dan Duncan Neurological Research Institute,Texas Children's Hospital, ⁵Department of Molecular and Human Genetics,Baylor College of Medicine, ⁶Department of Neuroscience,Baylor College of Medicine, ⁷Howard Hughes Medical Institute,Baylor College of Medicine

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