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Chapters
- 00:05Title
- 01:21Volume, Pressure, and Recording Measurements
- 02:59Gas Compression Correction
- 04:19Mouse PV Curve Measurement
- 07:38Results: Representative PV Curves
- 08:59Conclusion
Here we present a protocol to simply and reliably measure the lung pressure-volume curve in mice, showing that it is sufficiently sensitive to detect phenotypic parenchymal changes in two common lung pathologies, pulmonary fibrosis and emphysema. This metric provides a means to quantify the lung’s structural changes with developing pathology.
