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Chapters
- 00:05Title
- 00:57Introduction
- 01:31Preparing the Mouse for Surgery
- 03:16Surgical Prodcedure
- 09:20Representative Results
- 09:50Conclusion
This video shows how to induce abdominal aortic aneurysms (AAA) in mice via transient intraluminal infusion of porcine pancreatic elastase into the infrarenal segment of the abdominal aorta. The model has the ability to add broad insight into the pathobiology of AAA due to the emergence of numerous transgenic and gene knockout mice.
Tags
MurineExperimentalAbdominal Aortic AneurysmsElastaseIntraluminal InfusionPorcine Pancreatic ElastaseInfrarenal SegmentAbdominal AortaAnimal ModelDisrupted Nature Of ElastinPathobiology Of AAATransgenic MiceGene Knockout MiceTherapeutic AgentsElastase Infusion AAA ProcedureLaparotomySterile ConditionsOperating StereomicroscopeLigaturesAortotomyPolyethylene TubingPerfusion Catheter
