Waiting
로그인 처리 중...

Trial ends in Request Full Access Tell Your Colleague About Jove
Journal / Biology / Changes in Mammary Gland Morphology and Breast…
JoVE Journal
Biology

이 콘텐츠 오픈 액세스로 구독없이 시청하실 수 있습니다.

JoVE Journal Biology
Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats
 

Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats

Article DOI: 10.3791/2260-v • 09:36 min • October 16th, 2010
October 16th, 2010 •
1, 1,2, 1, 1
1Department of Oncology, Georgetown University, 2Institute of Biomedicine, University of Turku Medical Faculty

챕터

요약
Automatic Translation

Our protocol describes how to dissect the rat abdominal mammary gland and how to prepare mammary gland whole mounts. It also describes how to analyze mammary gland morphology using three end-points (number of terminal end buds, epithelial elongation and differentiation) and to use these results to predict mammary cancer risk in rats which were exposed to dietary modifications in utero or during prepuberty.

Tags

Mammary Gland Morphology Breast Cancer Risk Rats Dietary Factors Hormonal Factors In Utero Pubertal Periods Modeling And Re-modeling Susceptibility To Carcinogen-induced Tumors High Birthweight Soy Intake Prenatal And Postnatal Dietary Modifications Persistent Morphological Changes Epigenetic Modifications DNA Methylation Histones MiRNA Expression Gene Transcription Dissecting And Removing Abdominal Mammary Gland Preparing Mammary Gland Whole Mounts Analyzing Mammary Gland Morphology Terminal End Buds Epithelial Elongation And Differentiation Predicting Risk Of Developing Mammary Cancer
Read Article

Get cutting-edge science videos from JoVE sent straight to your inbox every month.

Waiting X
Simple Hit Counter