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压力控制通气诱导小鼠急性肺损伤
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JoVE 신문 의학
Pressure Controlled Ventilation to Induce Acute Lung Injury in Mice
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压力控制通气诱导小鼠急性肺损伤

DOI:
10.3791/2525-v

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07:55 min

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May 05, 2011

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, ,
1Department of Anesthesiology,University of Colorado

Chapters

  • 00:05Title
  • 01:10Surgical Preparation
  • 02:53Ventilator-induced Lung Injury
  • 04:52Sample Collection
  • 07:17Measurement of Lung Injury
  • 07:36Conclusion

Summary

자동 번역

자동 번역

一个呼吸机诱导肺损伤的小鼠模型是一个重要的工具，研究急性肺损伤<em>在体内</em>。在这里，我们报告一件容易的适用<em>原位</em>模型使用高压机械通气诱发急性肺衰竭的急性肺伤害。

Tags

Pressure Controlled VentilationAcute Lung InjuryALIMiceMurine ModelsMechanical VentilationGenetic TargetsPharmacological TargetsPulmonary EdemaPulmonary Gas ExchangeVentilator-induced Lung InjuryC57BL/6 MiceTracheotomyInspiratory Peak PressureOutcome ParametersWet-to-dry RatioBronchoalveolar Fluid Albumin ContentMyeloperoxidase ContentPulmonary InflammationTreatment GroupsGenotypesGene-targeted Deletion

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