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Myo-mechanical Analysis of Isolated Skeletal Muscle
 

Myo-mechanical Analysis of Isolated Skeletal Muscle

Article DOI: 10.3791/2582-v • 08:43 min • February 22nd, 2011
February 22nd, 2011 •
1,2, 3, 2, 4, 1,2,5
1Cardiovascular Research Institute, University of California San Francisco, 2Department of Pediatrics, University of California San Francisco, 3Department of Biology, San Francisco State University, 4Department of Medicine, University of California San Francisco, 5Eli and Edythe Broad Center of Regeneration Medicine & Stem Cell Research, University of California San Francisco

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요약
Automatic Translation

To assess the in vivo effects of therapeutic interventions for muscle disease, methods are needed to quantitate force generation and fatigability in treated muscle. We detail an approach to evaluating myo-mechanical properties in explanted mouse hindlimb muscle. This analysis provides a robust approach to quantitating the effects of genetic modification on muscle function, as well as comparison of therapies in mouse models of muscle disease.

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Myo-mechanical Analysis Isolated Skeletal Muscle Therapeutic Interventions Muscle Disease Quantitative Methods Force Generation Fatigability Hindlimb Muscle Explanted Muscle Muscle Strip Myograph Maximal Twitch Tension Tetanic Tension Contraction Time Half-relaxation Time Square Pulse Stimulator Specific Twitch Tension Specific Tetanic Tension Muscle Cross-sectional Area Twitch-to-tetanic Tension Ratio Force-frequency Relationship Curve Low Frequency Fatigue Curve Comparison Between Therapeutic Interventions Mouse Models Of Muscle Disease Genetic Modification Muscle Function
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