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Medicine

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Electrolytic Inferior Vena Cava Model (EIM) of Venous Thrombosis
 
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Electrolytic Inferior Vena Cava Model (EIM) of Venous Thrombosis

Article DOI: 10.3791/2737-v • 06:04 min • July 12th, 2011
July 12th, 2011 •
1, 1, 1, 2, 1, 1
1Conrad Jobst Vascular Research Laboratories, Section of Vascular Surgery, University of Michigan, 2Department of Pharmacology, University of Michigan

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The electrolytic induction of endothelial activation to the internal surface of the Inferior Vena Cava results in venous type thrombus formation due to endothelial activation and partial blood stasis, two components of Virchow's triad.

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Electrolytic Inferior Vena Cava Model EIM Venous Thrombosis Animal Models DVT Research Thrombus Formation Thrombus Resolution Therapeutic Compounds Potential Therapeutic Antagonist Compounds Thrombosed Vein Partial Stasis Major Vein Continuous Blood Flow Therapeutic Agents Dynamic Fashion Sensitivity Venous Endothelial Cell Activation Leukocyte Migration Venous Thrombogenesis Analytical Purposes
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