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Bioengineering

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JoVE Journal Bioengineering
The Three-Dimensional Human Skin Reconstruct Model
 
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The Three-Dimensional Human Skin Reconstruct Model: a Tool to Study Normal Skin and Melanoma Progression

Article DOI: 10.3791/2937-v • 11:02 min • August 3rd, 2011
August 3rd, 2011 •
1, 1, 1
1Molecular and Cellular Oncogenesis Program, The Wistar Institute

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In this report, we describe the three-dimensional skin reconstruct model which mimics human skin in architecture and composition. Melanocyte physiology, melanoma progression and the fate of dermal stem cells have been investigated using the skin reconstruct model. The model is also useful as a preclinical tool for drug assessment.

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Three-dimensional Human Skin Reconstruct Model In Vitro Studies Experimental Skin Biology 2-dimensional Monocultures 3D Extra-cellular Matrix Cell-cell Interactions Mouse Models Cellular Architecture Physiology Melanocytes Hair Follicles Basal Layer Of The Epidermis 3D Human Skin Reconstruct Models Dermis Fibroblasts Collagen I Matrix Epidermis Stratified Differentiated Keratinocytes Functional Basement Membrane Scaffolding Nutrient Delivery Cell-to-cell Interaction Melanocyte Homeostasis Melanoma Progression
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