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Chapters
- 00:05Title
- 01:56Collecting Baseline von Frey Measurements Prior to Surgery
- 03:04Anesthesia and Preparation for Surgery
- 04:14Surgery
- 06:04Post-surgical Care and von Frey Measurements
- 06:37Results: von Frey Testing of 8-10 Week-old Mice Before and After Surgery
- 07:17Conclusion
The Spared Nerve Injury animal model is described here as a mouse model of peripheral neuropathic pain following partial denervation of the sciatic nerve by lesioning the tibial and common peroneal nerve branches, leaving the remaining sural nerve intact. Behavioral modification resulting from mechanical allodynia is quantified by von Frey filaments.
Tags
Spared Nerve Injury (SNI) ModelPeripheral Neuropathic PainChronic Pain ConditionTrauma To Sensory NervesPeripheral Nervous SystemMechanical AllodyniaTactile StimuliSNI Mouse ModelLigation Of Sciatic Nerve BranchesTibial NerveCommon Peroneal NerveSural NerveHypersensitivity In Lateral Area Of PawControl SideVon Frey FilamentsBending ForcePain ReactionPaw WithdrawalFlinchingPaw LickingPain Threshold
