Autologous Endothelial Progenitor Cell-Seeding Technology and Biocompatibility Testing For Cardiovascular Devices in Large Animal Model

Alexandra E. Jantzen; Whitney O. Lane; Shawn M. Gage; Justin M. Haseltine; Lauren J. Galinat; Ryan M. Jamiolkowski; Fu-Hsiung Lin; George A. Truskey; Hardean E. Achneck

doi:10.3791/3197

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Autologous Endothelial Progenitor Cell-Seeding Technology and Biocompatibility Testing For Cardiovascular Devices in Large Animal Model

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Autologous Endothelial Progenitor Cell-Seeding Technology and Biocompatibility Testing For Cardiovascular Devices in Large Animal Model

DOI:

10.3791/3197-v

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11:49 min

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September 09, 2011

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Alexandra E. Jantzen, Whitney O. Lane, Shawn M. Gage, Justin M. Haseltine, Lauren J. Galinat, Ryan M. Jamiolkowski, Fu-Hsiung Lin, George A. Truskey, Hardean E. Achneck

¹Department of Biomedical Engineering,Duke University , ²School of Medicine,Duke University , ³Department of Surgery,Duke University Medical Center, ⁴School of Medicine,University of Pennsylvania

Chapters

00:05Title
02:12Preparing the EPCs for Seeding
04:01Porcine Implantation Surgery: Part 1
06:16Seeding the Implant
07:26Porcine Implantation Surgery: Part 2
09:39Representative Results
10:29Conclusion

Summary

자동 번역

A method for seeding titanium blood-contacting biomaterials with autologous cells and testing biocompatibility is described. This method uses endothelial progenitor cells and titanium tubes, seeded within minutes of surgical implantation into porcine venae cavae. This technique is adaptable to many other implantable biomedical devices.

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Autologous Endothelial Progenitor Cell-Seeding Technology and Biocompatibility Testing For Cardiovascular Devices in Large Animal Model

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Chapters

Summary

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