JoVE 비디오를 활용하시려면 도서관을 통한 기관 구독이 필요합니다. 전체 비디오를 보시려면 로그인하거나 무료 트라이얼을 시작하세요.
Chapters
- 00:05Title
- 01:00Setting up the Surgical Apparatus
- 04:20Unilateral 6-OHDA Lesion Surgery
- 08:46Representative Results for the Development of a Unilaterally-lesioned 6-OHDA Mouse Model of Parkinson’s Disease
- 09:40Conclusion
Un protocole pour effectuer unilatérales de 6-OHDA lésions du faisceau médian du cerveau antérieur chez la souris est décrite. Cette méthode a un faible taux de mortalité (13,3%) avec 89% des animaux qui ont survécu montrant la perte de> 95% de la dopamine striatale et 90,63 ± -4,02% biais ipsiversive rotation vers le côté de la lésion.
Tags
Unilaterally-lesioned 6-OHDA Mouse ModelParkinson’s DiseaseBasal Ganglia CircuitryParkinsonian SymptomsCortico-striatal SynapsesStriatumPathological AbnormalitiesNigro-striatal PathwayBacterial Artificial Chromosome (BAC) MiceGreen Fluorescent ProteinsDirect PathwayIndirect PathwaySynaptic PlasticityJuvenile MiceAcute Models Of Parkinsonism
