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Chapters
- 00:05Title
- 01:09Preparing the Shear Stress Modifier
- 01:59Implanting the Cuff Around the Right Carotid Artery
- 06:35Results: Shear Stress
- 07:33Conclusion
The constricting cuff presented in this article is designed to induce atherosclerosis in the murine common carotid artery. Due to the conical shape of its inner lumen the implanted cuff generates well-defined regions of low, high and oscillatory shear stress triggering the development of atherosclerotic lesions of different inflammatory phenotypes.
Tags
Carotid CuffShear StressAtherosclerosisInflammatory GenesEndothelial CellsFlow DynamicsSmall Animal ModelsPlaque DevelopmentCarotid Artery LigationEndothelial DysfunctionAtherosclerotic LesionsShear Stress Modifying CuffFluid DynamicsDefined Regions Of Shear StressCommon Carotid ArteryApolipoprotein E (ApoE) Knockout MiceHigh Cholesterol Diet
