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MAME的模型四维活细胞成像肿瘤微环境的相互作用，影响的恶性进展

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MAME Models for 4D Live-cell Imaging of Tumor: Microenvironment Interactions that Impact Malignant Progression

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MAME的模型四维活细胞成像肿瘤微环境的相互作用，影响的恶性进展

DOI:

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08:26 min

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February 17, 2012

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Mansoureh Sameni, Arulselvi Anbalagan, Mary B. Olive, Kamiar Moin², Raymond R. Mattingly², Bonnie F. Sloane²

¹Department of Pharmacology,Wayne State University , ²Barbara Ann Karmanos Cancer Institute,Wayne State University

Chapters

00:05Title
01:57Preparation of Mammary Architecture and Microenvironment Engineering (MAME) Cocultures
04:08Performing 4D (3D + time) Imaging of Live MAME Cocultures by Confocal Microscopy
05:11Representative 4D MAME Live-cell Imaging Models
07:57Conclusion

Summary

자동 번역

我们已经制定了活细胞成像在乳腺肿瘤细胞和其他细胞之间的相互作用，在自己的微实时三维共培养模型，侵入型的影响进展。这些模型可以作为目标旁诱导蛋白，趋化因子/细胞因子和蛋白激酶途径侵袭牵连的药物临床前屏幕。

Tags

MAME Models 4D Live-cell Imaging Tumor Microenvironment Interactions Malignant Progression Coculture Models Preinvasive Breast Lesions Invasive Phenotype Breast Epithelial Cells Tumor Microenvironment Myoepithelial Cells Fibroblasts Macrophages Blood And Lymphatic Microvascular Endothelial Cells Prostate Cancers 3D Cocultures Live-cell Imaging Functional Proteolysis Assay Breast Ductal Carcinoma In Situ (DCIS) Cells

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